Autoantibodies Flashcards Preview

Immunology > Autoantibodies > Flashcards

Flashcards in Autoantibodies Deck (22):
1

Goodpasture

Anti-BM

2

SLE, antiphospholipid syndrome

Anticardiolipin

3

Limited Scleroderma (CREST syndrome)

Anticentromere

4

Pemphigus vulgaris

Anti-desmosome (separate keratinocytes from basal layer of epidermis -- easily exfoliate)

5

SLE

Anticardiolipin, Anti-dsDNA, anti-Smith, Antinuclear antibodies (nonspecific)

6

T1DM

Anti-glutamic acid decarboxylase (GAD-65)

7

Bullous pemphigoid

Antihemidesmosome (between epidermis and dermis)

8

Drug-induced lupus

anti-histone

9

Polymyositis, dermatomyositis

anti-Jo-1, anti-SRP, anti-Mi-2

10

Hashimoto thyroiditis

Antimicrosomal, antithyroglobulin

11

Primary biliary cirrhosis

Antimitochondria

12

Pernicious anemia

Antiparietal cell

13

Diffuse scleroderma

Anti-Scl-70 (anti-DNA topoisomerase I)

14

Autoimmune hepatitis

anti-smooth muscle

15

Sjogren's syndrome

Anti-SSA, Anti-SSB (anti-Ro, anti-La)

(destroy salivary and lacrimal glands --> dry mouth and eyes)

16

Graves disease

anti-TSH receptor

17

Mixed CT disease

Anti-U1 RNP (ribonucleoprotein)

18

Celiac disease

IgA anti-endomysial, IgA anti-tissue transglutaminase

19

Microscopic polyangiitis and Churg Strauss

MPO-ANCA/p-ANCA

20

Granulomatosis with polyangiitis (Wegener)

PR3-ANCA/c-ANCA

21

RA

Rheumatoid factor (IgM that targets IgG Fc region) and anti-CCP

22

Myasthenia gravis

Anti-ACh receptor