Therapeutic antibodies Flashcards Preview

Immunology > Therapeutic antibodies > Flashcards

Flashcards in Therapeutic antibodies Deck (12):
1

Targets VEGF

Bevacizumab - treats CRC, RCCA

2

Targets EGFR

Cetuximab, treats CRC, head and neck cancer

3

Targets HER2/neu

Trastuzumab, treats breast cancer

4

Autoimmune disease therapy

Adalimumab, infliximab - targets TNF-alpha, treats IBD, RA, ankylosing spondylitis, psoriasis; Etanercept has same effect but is decoy TNF alpha receptor

Eculizumab - targets C5 to treat PNH

Natalizumab - targets alpha4-integrin, treats MS and Crohn dz

5

Disrupts WBC adhesion

Natalizumab (by inhibiting alpha4-integrin) - can --> PML in pts with JC virus

6

Abciximab

Targets plt glycoproteins IIb/IIIa - prevents ischemic complications during PCI

7

Denosumab

Targets RANKL - inhibits OC maturation to treat osteoporosis

8

Digoxin immune Fab

Targets digoxin - antidote for toxicity

9

Omalizumab

Targets IgE to treat allergic asthma

10

Palivizumab

Targets RSV F protein to prophylax high-risk infants

11

Ranibizumab, bevacizumab

Target VEGF and treat neovascular age-related macular degeneration

12

Cancer therapies

Alemtuzumab (targets CD52, treats CLL)

Bevacizumab (targets VEGF, treats CRC, RCCA)

Cetuximab (targets EGFR, treats CRC, head and neck ca)

Rituximab (targets CD20, treats B cell NHL, CLL, RA, ITP)

Trastuzumab (targets HER2/neu, treats breast cancer) - "tras2zumab"