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Pathology > Autoantibodies > Flashcards

Autoantibodies Flashcards

1
Q

Autoantibody: Anti-Ach receptor

A

Myasthenia gravis

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2
Q

Autoantibody: Anti-glomerular basement membrane

A

Goodpasture Syndrome

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3
Q

Autoantibody: Anticardiolipin, ___ anticoagulant

A

SLE, antiphospholipid syndrome

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4
Q

Autoantibody: Anticentromere

A

Limited scleroderma (Crest syndrome)

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5
Q

Autoantibody: Anti-desmosome (anti-desmoglein)

A

Pemphigus Vulgaris

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6
Q

Autoantibody: Anti-dsDNA, anti-Smith

A

SLE

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7
Q

Anti-glutamic acid decarboxylase (GAD-65)

A

Type 1 Diabetes Mellitus

Autoantibody AKA: islet cell cytoplasmic antibodies

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8
Q

Autoantibody: Antihemidesmosome

A

Bullous pemphigoid

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9
Q

Autoantibody: Anti-histone

A

Drug-induced lupus

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10
Q

Autoantibody: Anti-Jo-1, anti-SRP, anti-Mi-2

A

Polymyositis, dermatomyositis

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11
Q

Autoantibody: Antimicrosomal, antithyroglobulin, antithyroid peroxidase

A

Hashimoto Thyroiditis

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12
Q

Autoantibody: Antimitochondrial

A

Primary biliary cholangitis

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13
Q

Autoantibody: Antinuclear antibodies (ANA)

A

Nonspecific screening antibody, often associated with SLE

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14
Q

Autoantibody: Antiparietal cell, anti-intrinsic factor

A

Pernicious anemia

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15
Q

Autoantibody: Anti-Scl-70 (anti-DNA topoisomerase I)

A

Scleroderma (diffuse)

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16
Q

Anti-smooth muscle

A

Autoimmune hepatitis type 1

17
Q

Anti-SSA, anti-SSB (anti-Ro, anti-La)

A

Sjögren Syndrome

18
Q

Autoantibody: Anti-TSH receptor

A

Graves Disease

19
Q

Autoantibody: Anti-U1 RNP (ribonucleoprotein)

A

Mixed connective tissue disease

20
Q

Autoantibody: IgA anti-endomysial, IgA anti-tissue transglutaminase

A

Celiac disease

+ IgA and IgG deaminated gliadin peptide

21
Q

Autoantibody: MPO-ANCA/p-ANCA

A

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), Ulcerative Colitis

22
Q

Autoantibody: PR3-ANCA/c-ANCA

A

Granulomatosis with polyangiitis (Wegener)

23
Q

Autoantibody: anti-CCP (more specific)

A

Rheumatoid arthritis

Rheumatoid factor –> IgM antibody that targets IgG Fc region),

24
Q

Autoantibodies: Anti-phospholipase A2 receptor

A

Primary membranous nephropathy

25
Q

Antibodies: Anti-B2 (beta 2) glycoprotein

A

Antiphospholipid syndrome

26
Q

Antibodies: Anti-presynaptic voltage gated calcium channel

A

Lambert-Eaton myasthenic syndrome

27
Q

Autoantibody: Anti-IgG antibodies

A

Rheumatoid arthritis

28
Q

Autoantibody: Anti-citrullinated protein antibodies (ACPA)

A

Rheumatoid arthritis

Pathology (5 decks)

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