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Pathology > Pre-Cancer Dispositions > Flashcards

Pre-Cancer Dispositions Flashcards

1
Q

Rare paraneoplastic indicator of visceral malignancy…

A

Acanthosis nigricans

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2
Q

Precursor to esophageal adenocarcinoma…

A

Barrett esophagus

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3
Q

Predispose to gastric carcinoma

A

Chronic Atrophic gastritis, post surgical gastric remnants

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4
Q

Predisposes to hepatocelular carcinoma

A

Cirrhosis

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5
Q

Precursor to squamous cell carcinoma of the skin…

A

Actinic keratosis

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6
Q

Precursor to visceral malignancy, particularly genitourinary…

A

Dermato- and polymyositis

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7
Q

Precursor to malignant melanoma…

A

Dysplastic nevus

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8
Q

This dermatologic condition predisposes to GI, breast, lung, and lymphoid malignancies…

A

Multiple seborrheic keratosis

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9
Q

Predisposes to 2* osteosarcoma and fibrosarcoma…

A

Paget disease of the bone

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10
Q

Predisposes to squamous cell carcinoma of the esophagus

A

Plummer-Vinson Syndrome

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11
Q

Often manifests with multiple hamartomas (benign) tumors including giant cell astrocytomas, renal angiomyolipomas, Cardiac Rhabdomyomas; tumors may become malignant.

A

Tuberous sclerosis

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12
Q

Predispose to squamous cell carcinoma, basal cell carcinoma, and melanoma…

A

Xeroderma pigmentosusm, Albinism

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13
Q

Predisposes to aggressive lymphoma (non-Hodgkin) and…

A

HIV

HIV also predisposes to Kaposi Sarcoma

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14
Q

Predispose to lymphoma

A

Autoimmune diseases like Hashimoto thyroiditis, SLE, Vitiligo… etc.

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15
Q

Down syndrome predisposes to what blood disorder?

A

Predisposes to acute lymphocytic leukemia

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16
Q

Predisposes to lymphoma, melanoma, renal cell carcinoma

A

Immunodeficiency

17
Q

p53 mutation predisposes to various cancer types at a young age (e.g. Sarcoma, breast, leukemia, adrenal gland)

A

Li-Fraumeni Syndrome

18
Q

High risk of developing leukemia, sarcoma, papillary thyroid cancer, breast cancer

A

Radiation exposure

19
Q

Agent: 1,25-(OH)2 D3 (calcitriol) –> hypercalcemia… what is the associated neoplasm?

A

Hodgkin Lymphoma, non-Hodgkin Lymphoma

20
Q

Agent: ACTH –> Cushing Syndrome… what is the associated neoplasm?

A

Small cell lung carcinoma, renal cell carcinoma

21
Q

Agent: ADH –> SIADH… what is the associated neoplasm?

A

Small cell lung carcinoma, intracranial neoplasms

22
Q

Agent: Antibodies against presynaptic Ca2+ channels at the NMJ –> Lambert Eaton myasthenic syndrome… what is the associated neoplasm?

A

Small cell lung carcinoma

23
Q

Agent: Erythropoietin–> Polycythemia… what is the associated neoplasm?

A

Renal cell carcinoma, hemangioblastoma, hepatocellular carcinoma, leiomyoma, pheochromocytoma.

24
Q

Agent: PTHrP –> Hypercalcemia… what is the associated neoplasm?

A

Squamous cell lung carcinoma, renal cell carcinoma, breast cancer

25
Q

Carcinogens: Aflatoxins (Aspergillus)…

A

Hepatocellular carcinoma

26
Q

Carcinogens: Alkylating agents

A

Leukemia/Lymphoma

27
Q

Carcinogens: Aromatic amines (e.g. Benzidine, 2-naphthylamine)

A

Bladder- transitional cell carcinoma

28
Q

Carcinogens: Arsentic –> Liver, Lung, Skin…

A

Angiosarcoma, Lung cancer, squamous cell carcinoma

29
Q

Carcinogens: Asbestos

A

Bronchogenic carcinoma > mesothelioma

30
Q

Carcinogens: Carbon tetrachloride–> Liver

A

Centrilobular necrosis, steatosis (fatty change).

31
Q

Carcinogens: Cigarette –> bladder, cervix, esophagus, kidney, Larynx, Lung, Pancreas…

A

bladder: transitional cell carcinoma
cervix: cervical carcinoma
esophagus: squamous cell carcinoma/adenocarcinoma
kidney: Renal cell carcinoma
Larynx: squamous cell carcinoma
Lung: squamous cell and small cell carcinoma
Pancreas: Pancreatic adenocarcinoma

32
Q

Carcinogen: Ethanol

A

Esophagus- squamous cell carcinoma

Liver - hepatocellular carcinoma

33
Q

Carcinogen: Ionizing radiation:

A

Papillary thyroid carcinoma

34
Q

Carcinogen: Nitrosamines

A

Gastric cancer

35
Q

Carcinogen: Vinyl chloride

A

Liver - Angiosarcoma

Pathology (5 decks)

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