Autoimmune

Question 1

ANA is used to:

Answer 1

detect and monitor autoimmune disorders

Question 2

What are the primary diseases associated with ANA?

Answer 2

MCTDs and SLE

Question 3

What else could cause an elevated ANA?

Answer 3

autoimmune disease, RA, scleroderma, RA , sjogren and polimelitis

Question 4

How is ANA tested?

Answer 4

fluorescein stain - measuring the titers and pattern

Question 5

Homogenous ANA means?

Answer 5

SLE and MCTDs

Question 6

Speckled ANA means?

Answer 6

SLE, MCTDs, scleroderma, RA, Sjogren’s, poliomyelitis

Question 7

Nucleolar ANA means?

Answer 7

poliomyelitis, scleroderma

Question 8

periphery ANA means?

Answer 8

SLE

Question 9

What is RA less sensitive for?

Answer 9

Early RA

Question 10

What would be indicated with a high RF?

Answer 10

RA, autoimmune diseases (SLE and Hep C)

Question 11

What markers are increased in inflammation?

Answer 11

CRP, ESR

Question 12

Which marker is indicative of CREST syndrome?

Answer 12

Anticentromere antibody

Question 13

What is anticentromere antibody sensitive for?

Answer 13

CREST syndrome but NOT scleroderma

Question 14

is CRP or ESR more sensitive?

Answer 14

CRP

Question 15

What is released with necrotic tissue? (it is bound to it)

Answer 15

CRP

Question 16

What is CRP?

Answer 16

non specific indicator of inflammation

Question 17

What is ESR an indicator of?

Answer 17

non specific indicator of inflammation

Question 18

What is ESR a measure of?

Answer 18

the amount of time that it takes for the RBCs to settle into plasma or saline

Question 19

what test is elevated in patients with antiphospholipid syndrome associated with thrombosis, thrombocytopenia, CVA, multiple miscarriages

Answer 19

anticardiolipin antibody

Question 20

What diseases are associated with anticardiolipin antibody?

Answer 20

antiphospholipid syndrome and SLE

Question 21

If a patient presents with Calcinosis, Raynauds, esophageal syndrome, sclerodactyly, telangiectasia, what test would you perform?

Answer 21

anticentromere antibody

Question 22

What test can be performed to test for SLE but usually just performed to rule out renal involvement with SLE patients?

Answer 22

anti-nucleosome (anti- NCS)

Question 23

if a patient’s anti double strand DNA is highly elevated what would that mean?

Answer 23

good chance of SLE

Question 24

If a patient anti- double stranded (Anti-ds DNA) is slightly elevated what would you use to confirm lupus dx?

Answer 24

antinuceosome (anti-ncs)

Question 25

if you have a positive ANA and a negative anti-smith what would be the disease?

Answer 25

MCTDs

Question 26

What is Anti-CCP be used to test?

Answer 26

early RA (used in conjunction with RF)

Question 27

What test tests for SLE and MCTDs ?

Answer 27

ANA and Anti- ENA

Question 28

What does anti-smith test for?

Answer 28

SLE

Question 29

What test checks for renal involvement in SLE ?

Answer 29

anti nucleosome (anti- ncs)

Question 30

what test is used to diagnose and monitor SLE?

Answer 30

anti-double strand DNA (anti- ds DNA)

Question 31

What tests for SLE and MCTDs ?

Answer 31

anti-extractable nuclear antigen

Question 32

What test tests for SLE only

Answer 32

anti-smith

Question 33

if ANA is positive and you perform a anti extractable nuclear antigen and the anti smith is positive , what could it be?

Answer 33

SLE

Question 34

Anti-mitochondrial antibody (AMA) is used to test what?

Answer 34

diagnose primary biliary cirrhosis

Question 35

What do you need to diagnose hepatobiliary cirrhosis?

Answer 35

AMA and liver biopsy

Question 36

What does ASMA do?

Answer 36

detects the difference between autoimmune hepatitis and SLE

Question 37

What does AMA do?

Answer 37

diagnosis primary biliary cirrhosis

Question 38

What does ANCA test for?

Answer 38

diagnose wegener's granulomatosis

Question 39

What are the 2 staining patterns for ANCA?

Answer 39

P-ANCA (perinuclear) | C-ANCA (cytoplasm)

Question 40

Anti scleroderma antibody (Sc- 70 antibody) tests for what?

Answer 40

PSS with confirmatory biopsy

Question 41

What does a negative SC-70 mean?

Answer 41

does not necessarily mean that it is negative for PSS (progressive systemic scleroderma)

Question 42

If there is symptoms of sjrogens and Anti SS-A (Ro) is positive, what needs to be positive for a confirmation in diagnosis?

Answer 42

Anti-SS-B (la)

Question 43

What does Anti-SS-C test for?

Answer 43

RA and sjogrens