Autoimmune hepatitis Flashcards Preview

Gastrointestinal (LECTURE NOTES) > Autoimmune hepatitis > Flashcards

Flashcards in Autoimmune hepatitis Deck (12):
1

How is autoimmune hepatitis diagnosed

The presence of a constellation of clinical, laboratory and pathological features

2

What does autoimmune hepatitis usually respond to

Corticosteroid treatment,

3

What is common when steroids therapy is stopped

Relapses

4

What is the cause of autoimmune hepatitis

Unknown

5

Who is most commonly affected by autoimmune hepatitis

Young women but anybody can be affected

6

When is it common for AIH to recur or develop

After liver transplantation

7

What are the clinical features of AIH

May mimic acute viral or toxic hepatitis
Fatigue
amenorrhoea and those associated with an accompanying rheumatological disorder sucha s arthritis or thyroid disease

8

What are the physical findings of AIH

Jaundice
spider naevi
palmar erythema
hepatosplenomegaly

9

What are some of the investigations for AIH

Blood testing: Autoantibodies are the hallmark: anitnuclear factor and smooth-muscle antibodies

10

What can be useful in monitoring respone to treatment

Serum Ig levels

11

Why is liver biopsy essential

For both diagnosis and assessing the severity and to exclud other liver disease

12

What is the management of AIH

High dose corticosteroids (prednisolone for 4-6 weeks then tapered to a maintenance level
Keep liver enzymes in normal ranges
Azathioprine is added for its steroid sparing effect
Other immunosuppresives including tacrolimus
Liver transplantation