autoimmunity

Question 1

how many americans suffer from autoimmune disorders?

Answer 1

1 in 12

Question 2

Environmental triggers have helped to ______ disease rates

Answer 2

triple

Question 3

how many autoimmune diseases are there?

Answer 3

100

Question 4

why is there an increase in autoimmune diseases?

Answer 4

• environmental factors
• diet
• stress
• hormones
• aging

Question 5

do autoimmune diseases affect men or women more?

Answer 5

women

Question 6

autoimmune disease where antibodies or t cells to a single organ

Answer 6

organ specific

Question 7

graves disease organ specific or systemic?

Answer 7

organ specific

Question 8

T1D organ specific or systemic?

Answer 8

organ specific

Question 9

Goodpastures syndrome organ specific of systemic?

Answer 9

organ specific

Question 10

Addison disease organ specific or systemic?

Answer 10

organ specific

Question 11

thyroid stimulating Igs

Answer 11

Graves disease

Question 12

insulin receptor and other islet Ags

Answer 12

T1D

Question 13

basement membrane collagen in lungs and kidneys

Answer 13

goodpastures syndrome

Question 14

proteins in adrenal cortex

Answer 14

addison disease

Question 15

autoimmune disease where target antigens are among many tissues

Answer 15

systemic

Question 16

SLE organ specific or systemic?

Answer 16

systemic

Question 17

RA organ specific or systemic?

Answer 17

systemic

Question 18

Sjogren syndrome (SS) organ specific or systemic?

Answer 18

systemic

Question 19

Vasculitis organ specific or systemic?

Answer 19

systemic

Question 20

dsDNA and intracellular nucleoproteins; form large amounts of immune complexes

Answer 20

SLE

Question 21

antibodies to IgG fc and CCP, auto reactive T cells in joints

Answer 21

RA

Question 22

antibodies to ribonucleoproteins SSA and SSB

Answer 22

SS

Question 23

antibodies to neutrophil cellular ags

Answer 23

vasculitis

Question 24

Three interacting influences on development of autoimmune diseases

Answer 24

• genes
• immune regulation
• environment

Question 25

t/f MHC alleles strongly contribute to genetic susceptibility to autoimmune diseases

Answer 25

true

Question 26

failure to negatively select auto reactive clones or preferentially present autoantigens

Answer 26

differential selection

Question 27

How do infections facilitate autoimmunity?

Answer 27

activation of auto reactive b and t lymphocytes

Question 28

mechanisms of tissue damage and autoimmune diseases

Answer 28

- autoantibodies - auto reactive t cells - immune complex tissue deposition

Question 29

autoantibodies

Answer 29

- activate complement | - activate immune effector cells

Question 30

auto reactive t cells

Answer 30

- cytotoxic t cell destruction of tissue | - release inflammatory cytokines

Question 31

immune complex tissue deposition

Answer 31

activate complement and immune effector cells type ii autoimmunity

Question 32

type II autoimmunity

Answer 32

IgG mediated cytotoxic hypersensitivity

Question 33

type II autoimmunity example

Answer 33

hemolytic anemia

Question 34

type III autoimmunity

Answer 34

immune complex mediated hypersensitivity

Question 35

type III autoimmunity example

Answer 35

glomerulonephritis RA SLE

Question 36

type IV autoimmunity

Answer 36

cell mediated hypersensitivity

Question 37

type IV autoimmunity example

Answer 37

T1D MS RA

Question 38

Red wolf disease

Answer 38

SLE

Question 39

Chronic auto reactive IgG production

Answer 39

SLE

Question 40

Activation of auto reactive T cells and autoantibodies to CCP

Answer 40

RA

Question 41

Activation of auto reactive T cells and autoantibodies to myelin

Answer 41

MS

Question 42

Treatments for autoimmune diseases

Answer 42

- metabolic control - conventional immunosuppresants - biologicals

Question 43

what do biologicals target?

Answer 43

TNF-a

Question 44

types of autoimmune diseases

Answer 44

organ specific | systemic

Question 45

Metabolic control examples

Answer 45

- thyroxin - insulin - B12

Question 46

Immunosuppressant examples

Answer 46

- steroids | - nsaids

Question 47

biologicals examples

Answer 47

- Remade - Humira - Enbrel