Autoimmunity and autoantibodies Flashcards Preview

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Flashcards in Autoimmunity and autoantibodies Deck (16):
1

What is autoimmunity?

The immune system becomes dysfunctional and creates antibodies that attack the bodies own proteins.

2

Why are they seropositive?

The auto-antibodies can be found circulating in the serum of the blood.

3

How does autoimmunity occur?

The immune systems normal regulatory process fails and means they stop recognising proteins as there own. The immune system therefore starts producing antibodies against these (autoantibodies).

4

What causes autoimmunity?

Genetic predisposition plus environmental factors such as chemical exposure and infection.

5

Which disease/diseases is Anti-nuclear antibody associated with?

SLE, sjogrens, systemic sclerosis, MCTD and autoimmune liver disease.

6

Which disease/diseases is anti-Ro antibody associated with?

SLE, sjogrens disease

7

Which disease/diseases are anti-CCP antibody associated with?

Rheumatic arthritis

8

Which disease/diseases are anti-double stranded DNA associated with? (dsDNA)

SLE

9

Which disease/diseases are Anti-sm associated with?

SLE

10

Which disease/diseases are Anti-La antibodies associated with?

Sjogrens syndrome

11

Which disease/diseases is anti-centromere antibody associated with?

Systemic sclerosis (limited)

12

Which disease/diseases are anti Scl 70 antibody associated with?

Systemic sclerosis (diffuse)

13

Which disease/diseases are associated with anti-RNP antibody?

SLE, mixed connective tissue disease

14

Which disease/diseases are Anti-Jo-1 antibodies associated with?

Myositis

15

Which disease/diseases are anti-cardiolipin antibody and lupus anti-coagulant associated with?

Antiphospholipid syndrome

16

Which disease/diseases are anti-neutrophil cytoplasmic antibody (ANCA) associated with?

Small vessel vasculitis.