Flashcards in Autoimmunty Deck (14)
What cell type can override Treg cells?
Th17 by releasing IL-17
What's the difference between an autoimmune reaction and an autoimmune disease?
A disease is pathological and cause harm to tissues/organs
A reaction can be part of the normal bodily processes, attacking cells that are damaged, in the wrong place or neoplastic
Autoimmune diseases can be split into 2 categories?
Organ specific with a single tissue specific Ab e.g. Anti-GAD
Non-Organ Specific with non-specific Abs e.g. ANA
Give some examples of organ specific autoimmune diseases?
Type 1 DM
Give some examples of non-organ specific autoimmune disorders?
Try to list 5 different mechanisms of autoimmune disease?
1) Cell Mediated Autoimmunity
2) Antibody Mediated (Type 2 hypersensitivity)
3) Immune complex mediated (Type 3 hypersensitivity)
4) Innate Recruitment
5) Molecular Mimicry
What conditions operate by cell mediated autoimmunity/
Type 1 DM
T & NK cells are involved
What major conditions operate by antibody mediated autoimmunity?
What happens in good pastures syndrome?
Anti-GBM Abs react to type 4 collagen in the basement membrane --> lung haemorrhage & glomerulonephritis
What happens in Myasthenia GRavis?
Auto-reactive T cells & Anti-Ach receptor Abs attach to receptors at NMJ --> Muscle weakness & fatigueability
It's primarily an Ab disorder but T cells are involved hence why we look for and resect thymomas
Give an example of an Immune Complex mediated autoimmune disorder?
How does molecular mimicry work?
Pathogen or other molecule (e.g. penicillin) mimics your own cell's antigen
--> Body attacks that antigen and then your own one too
Example of a condition that works by molecular mimicry?
Strep carries an antigen very similar to that found on muscle cells --> Myocardial damage and myositis