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Flashcards in E-learning Deck (9)
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1

What are MHC proteins?

aka HLA proteins in humans

They're proteins on the cell surface that present foreign antigens and self-antigens to the immune system

2

What do MHC1 do?

Present self-markers on all nucleated cells

Also present endogenous antigens of intracellular pathogens e.g. Viruses

3

What do MHC2 do?

Present exogenous antigens of extracellular pathogens e.g. bacteria on all professional APCs (e.g. Dendritic, macrophage & B lymphocytes)

4

What immune cells recognise MHC1?

CD8 Tc Cells
Nk Cells

5

What immune cells recognise MHC2?

CD4+ Th cells

6

Where do central and peripheral tolerance occur?

Central in bone marrow and thymus

Peripheral in blood (by Treg cells)

7

What are the main 8 physical barriers of the immune system?

- Lysozymes in tears, saliva & sweat
- Mucocillary escalator
- Intact skin
- Intact mucosal membranes
- Acidic pH of stomach
- Alkaline pH of small bowel and rapid change in duodenum
- Normal bowel, vaginal and skin flora
- Urinary Tract Flushing

8

What cells phagocytose?

Macrophages
Basophils
Neutrophils
Monocytes

9

What cells dealt with parasites and other organisms too big for phagocytosis?

Mast Cells
Basophils
Eosinophils