AWABS - Ageing and Frailty Flashcards
Effects of ageing on cardiovascular system
Reduced CO due to increased SVR and reduced cardiac contractility
Effects of ageing on renal system
Reduced renal mass
Reduced glomerular filtration
Reduced drug clearance
Effects of ageing on respiratory system
Reduced elastic recoil
Reduced lung volume
Increased ventilation-perfusion mismatch
Effects of ageing on musculoskeletal system
Sarcopenia
Reduced muscle mass and therefore impaired thermoregulation
Effects of ageing on CNS
Reduced cortical volume
Reduced synaptic density
Reduced processing speed
Higher susceptibility to delirium
Effects of ageing on GI system
Reduced acid secretion
Reduced drug absorption
Effects of ageing on hepatic system
Reduced volume
Reduced blood flow
Reduced first pass metabolism
Reduced drug clearance
Effects of ageing on bone
Reduced bone mineral density
Increased fracture risk
Frailty definition
Clinically recognisable state
(Aging-related) syndrome of physiological decline, characterised by marked vulnerability to adverse health outcomes / stressors
Features of frailty
Falls
Delirium
Incontinence
Poor mobility
Frailty scoring systems
(Rockwood) Clinical Frailty Scale
Fried frailty phenotype
Edmonton frailty score
Rockwood clinical frailty scale
Caveats to Rockwood clinical frailty scale
User dependent
Not validated in under 65 year olds
Screening tool
Fried frailty ‘phenotype’ criteria
Deemed frail if 3 or more of:
- Unintentional weight loss
- Self reported exhaustion
- Low physical activity
- Slowness of gait
- Weakness (grip strength)
Edmonton frailty score
