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Flashcards in Bacterial Infections Deck (44)
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1

Tx for neonatal profylaxis of gonorrhea and chlamydia

Erythromycin ointment

2

Tx for bacterial conjunctivitis

Gentamycin, Tobramycin (Aminoglycosides)

or

Azithromycin (Macrolide)

or

Bactrim (sulfa)
**ADR, corneal ulcer** Interacts w SILVER

or

Ofloxacin, Ciprofloxacin, etc (Fluoro)
**ADR, photophobia**

3

Tx for acute otitis externa

1. Acetic Acid (mild)

2. Polymyxin B / Neomycin Drops

4

Tx chronic otitis externa

Polymyxin B / Neomycin drops

5

Tx for "malignant " otitis externa - usually caused by pseudomonas, DM patients more prone - infection has spread to surrounding tissue / bone

Medical emergency, IV antibiotics and debridement

6

1st line Tx for Acute Otitis Media

Amoxacillin

Augmentin with resistance

7

PCN allergic Tx for acute otitis media

Cefdinir or Ceftriaxone

If anaphylaxis Rx >> Macrolide (Clarithro, Azithro)

8

Gonorrhea and Chlamydia, treating togehter

Ceftriaxone IM + Azithromycin

9

Nasal decolonization of MRSA

Mupirocin

10

Tx for bacterial sinusitis, 1st line and PCN allergic

1. Augmentin (after 2 weeks of sinusitis)

PCN allergic: Cephalsporin (Cefdinir, Ceftriaxone)
if Analphylactic allergic: Macrolide (Clarithro, Azithro)

11

1st line Tx Strep Pharyngitis

Augmentin
or
Amoxiicllin / Ampicillin
or
Pen VK **black hairy tongue**

12

Tx for PCN allergic, Strep Pharyngitis

Cephalosporins

1st gen: Ceph-alexin, Ceph-adroxil, Cef-azolin

2nd gen: Cef-prozil, Cef-otetan, Cef-uroxime

3rd gen: Ceftriaxone?

4th gen: Cefepime

5th gen: Ceftaroline (MRSA)

13

1st line Tx for CAP, outpatient, no use of abx in the past 3 months

(Most like S. pneumonia)

1. Azithromycin, Clarithromycin, Erythromycin (Macrolides)

14

1st line Tx for CAP, outpatient, WITH CHRONIC DZ or use of and in past 3 months

1. Respiratory Fluoroquinolone
Moxifloxacin, Gemifloxacin, Levofloxacin

15

2nd line Tx for CAP, outpatient, WITH CHRONIC DZ or use of abx in past 3 months

Amoxicillin / Augmentin + Azithro or Clarithro

PCN allergic:

Ceftriaxone + Azithro or Clarithro

16

1st line Tx for CAP INPATIENT, non-ICU

**also good for PCN allergic**

Moxi, Levo, Gemi (resp fluoroquinolone)

**also good for PCN allergic**

17

2nd Line Tx for CAP INPATIENT, non-ICU

(same as 2nd line CAP outpatient w chronic dz)

Amoxicillin / Augmentin + Azithro or Clarithro

PCN allergic:

Cetriaxone + Azithro or Clarithro

18

1st line Tx for CAP, INPATIENT ICU

Cefotaxime, Ceftriaxone, Ampicillin + Levo, Moxi, Gemi

PCN allergic: AZTREONAM + Levo, Moxi, gemi

19

Notable ADR of Fluoroquinolones

Joint cartilage injury in kids <16 yrs

20

Tx for known pseudomonas infection

Levofloxacin + B Lactam + Gentamycin (Aminoglycoside)

21

Fluoroquinalones interact with what common OTC medication

Antacids! (Mg, Ca)

Separate dose by 2 hours

22

Fluoroquinolone MOA

Inhibit DNA gyrase and Topoisomerase IV (X DNA)

23

1st line HAP Tx, no MDR risks, not recent abc use

Levofloxacin

24

1st line HAP Tx, MRSA or mortality risks

Levofloxacin + LINEZOLID or VANCOMYCIN

25

Pertussis Tx, 1st line

Clarithromycin

26

Pertussis Tx, 2nd line

Sulfa Trimethoprime

27

Sulfonamide MOAs

Inhibits biosynthesis of bacterial nucleic acids and proteins (X DNA)

Bacteriocidal

28

Macrolide MOAs

Inhibit protein synthesis by binding 50 S ribosome (X DNA)

Bacteriostatic

29

Macrolides and P450

Azithromycin is NOT a P450

Erithro and Clarithro P450!! -
show up in Breast Milk and Cross Placenta

30

1st line for sepsis caused by Community Acquired Pneumonia, Skin and Soft Tissue Disease and Meningitis

Vancomycin

1. with Levo for CAP

2. with Ceftriaxone, Ampicillin, and Dexamethasone for Meningitis

3. Piperacillin or tazobactam for STD

31

1st line for sepsis caused by Intra-abdominal infections, Pelvic or UTI

Piperacillin or Tazobactam

with Gentamycin

32

Gonorrhea Tx

1st line: Ceftriaxone with Azithromycin (presumptive tx of chlamydia too)

33

Ceftriaxone IM - the shot MUST be given with what??

LIDOCAINE - very painful IM shot

34

1st line Lyme Disease Tx

Doxycycline

or Amoxicillin / Ampicillin

35

Notable Doxycycline ADRs and warnings

Teeth discoloration
Black tongue

Preg D

DON'T TAKE W DAIRY

36

Perioperative Prophylaxis

CEFAZOLIN (1st gen cef)

37

1st line Tx Uncomplicated UTI

(Absence of fever, flank pain, or other
suspicion for pyelonephritis
Able to take oral medication)

Sulfa Trimethoprime
(avoid if used recently for UTI or if known resistance)

or

Nitrofurantoin

or

Fosfomycin

38

Pyelonephritis or Complicated UTI

Ciprofloxacin

Levofloxacin
(unless there is known community resistance)

39

Black Box warning for Fluoroquinalones

Tendon issues, esp in adolescents

40

1st line Tx ,Bacterial Vaginitis

Metronidazole

41

Metronidazole ADRs and warnings

Metallic taste

Alcohol toxicity, into with Disulfiram

NO USE IN 1ST TRIMESTER PREGNANCY

42

2nd line Tx, Bacterial vaginitis (if early preg or alcoholic)

Clindamycin

43

1st line Tx Oncomycosis

Efinaconazole

44

C diff Tx

Metronidazole

Vancomycin PO

Fidaxomycin