Bacterial Toxin MOAs Flashcards Preview

BOARDS > Bacterial Toxin MOAs > Flashcards

Flashcards in Bacterial Toxin MOAs Deck (19)
Loading flashcards...
1
Q

Bacillus anthracis (edema factor)

A

Mimics the adenylate cyclase enzyme (inc. Camp) – Responsible for endematous borders of black eschar in cutaneous anthrax

2
Q

Bacillus anthracis (lethal factor)

A

Kills the cell – quoting micro notes.

3
Q

Bordetella pertussis

A

Pertussis toxin: Inhibits Gi which increases cAMP. This impairs phagocytosis and allows for bugs survival

4
Q

Clostridium botulinum

A

Inhibits Ach release by cleaving SNARE protein required for neurotransmitter release

5
Q

Clostridium difficile (toxin A, toxin B)

A

Toxin A = binds the brush border of the gut

Toxin B = cytotoxin that destroys the cytoskeletal structure of enterocytes causing the pseudomembranous colitis

6
Q

Clostridium perfringens (alpha toxin)

A

Phospholipase that degrades tissue and cell membranes

7
Q

Clostridium tetani

A

Prevents release of inhibitory (GABA and glycine) NT in spinal cord. Does this by cleaving SNARE protein required for NT release

8
Q

Corynebacterium diphtheriae

A

Inactivates elongation factor 2 (EF-2) – same MOA as P. aeruginosa

9
Q

EHEC

A

Shiga-like toxin - Inactivates 60S ribosome by removing adenine from rRNA.

10
Q

ETEC (heat-labile toxin)

A

“Labile in the Air and Stable on the Ground” –

Labile = increases cAMP which pumps Cl- into the gut

11
Q

ETEC (heat-stable toxin)

A

“Labile in the Air and Stable on the Ground” –

Stable = increases cGMP

12
Q

Lipopolysaccharide (endotoxin)

A

Outer cell membrane of gram negs. Induces TNF and IL-1 release

13
Q

Pseudomonas aeruginosa

A

Inactivates elongation factor 2 (EF-2) – same MOA as C. diphtheriae

14
Q

Shigella species

A

Inactivates 60S ribosome by removing adenine from rRNA. Can also cause cytokine release

15
Q

Staphylococcus aureus (enterotoxin)

A

Rapid-onset food poisoning – Mast cells responsible for emesis

16
Q

Staphylococcus aureus (exfoliative toxin)

A

Scalded skin syndrome – toxin acts as a protease causing peeling of the skin.

17
Q

Staphylococcus aureus (TSST-1)

A

Two main VF that are superantigens: S. aureus’s TSST-1, and S. pyo’s Exotoxin A.

Brings MHCII and TCR together and causes release of IFN-gamma and IL-2 causing shock.

18
Q

Streptococcus pyogenes (streptolysin O)

A

Causes the RBC hemolysis

19
Q

Vibrio cholerae

A

Permanently activates Gs causing increase in cAMP and inc. Cl- secretion into the gut = rice water diarrhea