Bacterial Toxin MOAs Flashcards Preview

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Flashcards in Bacterial Toxin MOAs Deck (19):
1

Bacillus anthracis (edema factor)

Mimics the adenylate cyclase enzyme (inc. Camp) – Responsible for endematous borders of black eschar in cutaneous anthrax

2

Bacillus anthracis (lethal factor)

Kills the cell – quoting micro notes.

3

Bordetella pertussis

Pertussis toxin: Inhibits Gi which increases cAMP. This impairs phagocytosis and allows for bugs survival

4

Clostridium botulinum

Inhibits Ach release by cleaving SNARE protein required for neurotransmitter release

5

Clostridium difficile (toxin A, toxin B)

Toxin A = binds the brush border of the gut
Toxin B = cytotoxin that destroys the cytoskeletal structure of enterocytes causing the pseudomembranous colitis

6

Clostridium perfringens (alpha toxin)

Phospholipase that degrades tissue and cell membranes

7

Clostridium tetani

Prevents release of inhibitory (GABA and glycine) NT in spinal cord. Does this by cleaving SNARE protein required for NT release

8

Corynebacterium diphtheriae

Inactivates elongation factor 2 (EF-2) – same MOA as P. aeruginosa

9

EHEC

Shiga-like toxin - Inactivates 60S ribosome by removing adenine from rRNA.

10

ETEC (heat-labile toxin)

“Labile in the Air and Stable on the Ground” –
Labile = increases cAMP which pumps Cl- into the gut

11

ETEC (heat-stable toxin)

“Labile in the Air and Stable on the Ground” –
Stable = increases cGMP

12

Lipopolysaccharide (endotoxin)

Outer cell membrane of gram negs. Induces TNF and IL-1 release

13

Pseudomonas aeruginosa

Inactivates elongation factor 2 (EF-2) – same MOA as C. diphtheriae

14

Shigella species

Inactivates 60S ribosome by removing adenine from rRNA. Can also cause cytokine release

15

Staphylococcus aureus (enterotoxin)

Rapid-onset food poisoning – Mast cells responsible for emesis

16

Staphylococcus aureus (exfoliative toxin)

Scalded skin syndrome – toxin acts as a protease causing peeling of the skin.

17

Staphylococcus aureus (TSST-1)

Two main VF that are superantigens: S. aureus’s TSST-1, and S. pyo’s Exotoxin A.

Brings MHCII and TCR together and causes release of IFN-gamma and IL-2 causing shock.

18

Streptococcus pyogenes (streptolysin O)

Causes the RBC hemolysis

19

Vibrio cholerae

Permanently activates Gs causing increase in cAMP and inc. Cl- secretion into the gut = rice water diarrhea