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Flashcards in Most Important Virulence Factors Deck (31):
1

Acute glomerulonephritis

M protein:
mimicry of basement membrane s/p strep pyo infection

2

Anthrax

Edema Factor:
Mimics cAMP

3

Botulism

Botulinum toxin:
Cleaves SNARE, which is required for NT release; Prevents release of stimulatory signal (ACH)

4

Cholera

Cholera toxin:
Activates Gs--> increase cAMP --> increase Cl and H2O efflux

5

Diphtheria

Diphtheria toxin:
Inactivate elongation factor

6

Escherichia coli meningitis

K capsule:
Crosses BBB

7

Escherichia coli UTI

Pili/fimbriae:
Borrows into bladder wall

8

Gas gangrene

LOS:
Inflammatory response, activates complement, then lyses phagosomes and that is what creates the purulent discharge. activation of inflammatory resposne = majority of sx

9

Gram-negative septic shock

LPS:
Free LPS binds protein--> activates monocytes--> CD14; signalling via TLR; fever cytokines released

10

Hemolytic uremic syndrome

EHEK Shiga-Like:
Inactivate 60s ribosome by removing adenine from rRNA

11

Kidney stones

Ureases+:
Proteus bugs

12

Klebsiella pneumoniae pneumonia

Polysacchraide capsule:
Resists complement mediated killing; resistance to phagocytosis; stops the amt of C3 placed on the bacteria so limits opsinization

13

Listeriosis

Listeriolysin O:
Hemolysin; lysing the phagolysosome

14

Meningococcal meningitis

Neisseria; polysaccharide capsule:
Avoid host phagocytosis

15

Meningococcal septic shock

LOS Neisseria:
Endotoxin; destroys rbc

16

Pneumococcal pneumonia/meningitis

Polysaccharide capsule:
Avoid host phagocytosis

17

Peptic ulcers

Cytotoxin assoc gene (CAGa):
H pylori

18

Pseudomembranous colitis

Toxin B (cytotoxin):
Cytoskeletal disruption via ACTIN DEPOLYMERIAZATION

19

Pseudomonal pneumonia

Biofilm:
Assoc with Cystic fibrosis

20

Pseudomonal wound infection

Exotoxin A:
Inactivates EF-2

21

Rheumatic fever

M protein:
Molecular mimicry

22

Scalded skin syndrome

Exfoliative toxin (s. aureus): Hydrolyzes proteins on the skin--> peeling

23

Scarlet fever

Pyrogenic erythrogenic:
SPE: damage plasma membrane of blood capillaries

24

Shigellosis

Shiga Toxin (ST):
Inactivate 60s ribosome by removing adenine from rRNA

25

Staphylococcal food poisoning

Enterotoxin B:
Heat stable; superantigen leads to increase in cytokines;

26

Strep throat

Streptolysin O

27

Tetanus

Tetanospasmin:
Cleave SNARE, which is required for NT release; prevents release of inhibitory (GABA)

28

Toxic shock syndrome

TSST (s.aureus)/Exotoxin S.pyo: Brings MHC II and TCR into proximity outsside the binding grove--> cytokine storm (inf gamm. IL2)

29

Traveler’s diarrhea

Heat labile, heat stable: ETEC
o Heat-Labile (LT): overactivates adenylate cyclase (cAMP) --> increase Cl secretion in gut and H20 efflux
o Heat-Stable (ST): overactivates guanylate cyclase (cGMP) --> decrease resorption of NaCl and H20 in the gut

30

Tuberculosis

Cord factor:
Inhibits macrophage maturation and induces release of TNFa

31

Whooping cough

Pertussis :
Disables Gi --> increase in cAMP; impairs phagocytosis