Flashcards in Basal Ganglia Deck (12):
What is the overall purpose of the basal ganglia?
Important in making voluntary movements, postural adjustments. Receives input from cortex, and then provides feedback to cortex to modulate movement
What is the striatum?
Receives input from cortex. Composed of Caudate (cognitive) and Putamen (motor).
What is the lentiform part of the basal ganglia?
Putamen + globus pallidus
What is the purpose of the "direct" pathway?
What is the purpose of the "indirect" pathway?
What input does the thalamus give to cortex?
What neurotransmitter does the substantia nigra pars compacta use?
Where are dopamine receptors in the basal ganglia?
Striatum. D2 in the INHIBITORY pathway, D1 in the DIRECT pathway.
What is the effect of dopamine on D1 receptors? on D2 receptors? Overall?
Dopamine stimulates D1 receptors (excitatory pathway).
Dopamine inhibits D2 receptors, part of inhibitory pathway.
Overall, dopamine is excitatory.
What is the direct pathway?
Cortex --> Striatum (stim)
Striatum ---> GPi/SNr (inhibit)
Gpi/SNr --> Inhibs thalamus LESS
Thalamus --> excite cortex
What is the role of the substantia pars compacta in the direct pathway?
Dopamine to D1 of striatum (stimulate).