Basics

Question 1

The effects of the drug on the body

Answer 1

Pharmacodynamics

Question 2

The fraction of administered drug that reaches systemic circulation unchanged.

Answer 2

Bioavailability

Question 3

The time required to change the amount of drug in the body by 1/2 during elimination.

Answer 3

Half life

Question 4

Rate of elimination is constant.

Answer 4

Zero order elimination

Question 5

Rate of elimination is directly proportional to the drug concentration.

Answer 5

First-order elimination

Question 6

Drugs that undergo Zero order elimination

Answer 6

WHAT PET

Warfarin
Heparin
Aspirin
Tolbutamide
Phenytoin
Ethanol 
Theophylline

Question 7

The effects of the body on the drug

Answer 7

Pharmacokinetics

Question 8

Phase 2 of Drug metabolism

Answer 8

Conjugation

Yields very polar, inactive metabolites

Question 9

Phase 1 of drug metabolism

Answer 9

Convert parent drug to a more polar, or more reactive product.

HYDROLYSIS
OXIDATION
REDUCTION
DEAMINATION

“a HORDe of phase 1 reaction.”

Question 10

aka Mixed Function Oxidases

Answer 10

Cytochrome P450 enzymes

Question 11

Refers to the maximal effect a drug can produce.

Answer 11

EFFICACY

Question 12

Drugs classes with High efficacy

Answer 12

Analgesics
Antibiotics
Antihistamines
Decongestants

Question 13

Refers to the amount of drug needed for a given effect

Answer 13

POTENCY

Question 14

Highly potent drug classes

Answer 14

Chemotherapeutics
Anti HPN
Lipid lowering drugs

Question 15

Refers to measurement of drug safety

Answer 15

Therapeutic Index

Question 16

A drug for a rare disease is called

Answer 16

Orphan drug

Question 17

When giving Cholinomimetic agents, what are to watch out for?

Answer 17

Exacerbation of COPD, asthma, and peptic ulcers.