Everything

Question 1

MOA of ASA

Answer 1

Irreversible COX1 and 2 inhibitor.

Reduces platelet production thromboxane A2

Question 2

Effect of ASA in children

Answer 2

Reye’s Syndrome

Question 3

Lethal dose in Aspirin Overdose

Answer 3

30g

60 ASA 500mg tabs

Question 4

MOA of Ibuprofen

Answer 4

Nonselective reversible COX 1 and 2 inhibitor

Question 5

Long term use effect of Ibuprofen

Answer 5

Reduce risk of colon cancer

Question 6

Use of Ketorolac

Answer 6

A nonselective NSAID

Post surgical analgesic control- short term

Generally restricted to 72hours use only

Question 7

COX 2 inhibitors that cause MI and stroke

Answer 7

Rofecoxib

Valdecoxib

Question 8

Antidote for Acetaminophen toxicity

Answer 8

NAC

Question 9

Lethal dose of Paracetamol toxicity

Answer 9

15g

30 paracetamol 500mg

Question 10

Examples of DMARDs

Answer 10

Methotrexate
Infliximab
Azathioprine
Chloroquine
Cyclophosphamide
Cyclosporine
Mycophenolate mofetil
Sulfasalazine

Question 11

MOA of Methotrexate

Answer 11

Inhibit AICAR transformylase and Thymidylate synthetase

Question 12

Classifications of NSAIDs

Answer 12

Salicylates- aspirin
Nonselective NSAIDs- ibuprofen, indomethacin, ketorolac, piroxicam
COX 2 selective- celecoxib, etoricoxb, parecoxib

Question 13

MOA of Infliximab

Answer 13

Binds to TNF-a and prevents it from activating TNF-a receptor

Question 14

Side effect of Cyclophosphamide

Answer 14

Hemorrhagic cystitis

Question 15

What alpha blocker is used preoperatively in px with pheochromocytoma? And why?

Answer 15

PHENOXYBENZAMINE

to prevent catecholamine (hypertensive) crisis

Question 16

What are the classes of anti-arrhythmic drugs?

Answer 16

Class 1- Na channel blockers
Class 2- Beta adrenoceptor blockers
Class 3- K channel blockers
Class 4- Ca channel blockers

Question 17

What are the non selective beta blockers?

Answer 17

N to Z

Nadolol
Pindolol
Propranolol
Timolol

Question 18

What are the beta 1 selective antagonists?

Answer 18

A to M

Acebutolol
Atenolol
Betaxolol
Esmolol
Metoprolol

Question 19

What drugs are both beta and alpha antagonists?

Answer 19

Carvedilol

Labetalol

Question 20

Shortest acting beta blocker

Answer 20

ESMOLOL

Question 21

Longest acting beta blocker

Answer 21

Nadolol

Question 22

Which microbes are covered by first gen. Cephalosporins?

Answer 22

PEcKs FIRST

PROTEUS MIRABILIS
ESCHERICHIA COLI
KLEBSIELLA PNEUMONIAE

Question 23

First gen. Cephalosporins

Answer 23

FADer, help me FAZ my PHarmacology boards!

CeFADroxil
CeFAZolin
CePHalothin
CePHaperin
CePHradine
CePHalexin

Question 24

Cephalosporins: disulfiram reaction

Answer 24

Sec gen:
Cefamandole
Cefotetam

Third gen:
Cefoperazone

Question 25

Which microbes are covered by second gen. Cephalosporins?

Answer 25

HEN PEcKS ``` H. Influenzae Enterobacter aerogenes Neisseria spp. Proteus E. Coli K. Pneumoniae Serratia marcescens ```

Question 26

Second gen. Cephalosporins

Answer 26

In a FAMily gathering,you see your FOXy cousin wearing a FUR coat and drinking TEA CeFAMandole CeFOXitin CeFURoxime CefoTEtan

Question 27

Rapid IV infusion of Vancomycin leads to?

Answer 27

Red Man Syndrome Diffuse flushing Histamine release

Question 28

What antibiotics are considered drugs of last resort?

Answer 28

I AM your Last Shot at Victory ``` Imipenem Amikacin Meropenem Linozelid Streptogramins Vancomycin ```

Question 29

What antibiotic causes Myopathy? What laboratory parameter needs to be monitored?

Answer 29

Daptomycin Creatine phosphokinase

Question 30

T or F: Aminoglycosides require oxygen for transport

Answer 30

T Ineffective against anaerobes

Question 31

List of Aminoglycosides

Answer 31

Mean GNATS canNOT kill anaerobes ``` GENTAMICIN NEOMYCIN AMIKACIN TOBRAMYCIN STREPTOMYCIN ``` Nephrotoxicity Ototoxicity Teratogen

Question 32

Most vestibulotoxic and nephrotoxic among aminoglycosides

Answer 32

Gentamicin and Tobramycin

Question 33

Aminoglycoside: least resistance but with narrowest therapeutic window

Answer 33

Amikacin

Question 34

Most ototoxic aminoglycoside

Answer 34

Kanamycin | Amikacin

Question 35

Aminoglycoside used in drug resistant gonorrhea, gonorrhea in penicillin allergic px

Answer 35

Spectinomycin

Question 36

Most nephrotoxic aminoglycoside

Answer 36

Tobramycin | Gentamicin

Question 37

Aminoglycosides with skin reactions as SE

Answer 37

Neomycin Streptomycin

Question 38

Weakly acidic compounds that have a common chemical nucleus resembling p-aminobutyric acid (PABA)

Answer 38

Sulfonamides

Question 39

Classification of Sulfonamides

Answer 39

Short acting- SULFISOXAZOLE intermediate acting- SULFAMETHOXAZOLE Long acting- SULFADOXINE

Question 40

Structurally similar to folic acid. A weak base that is trapped in acidic envt

Answer 40

Trimethoprim

Question 41

1st generation Fluoroquinolones

Answer 41

Nalidixic acid Cinaxacin Rosoxacin

Question 42

Second generation fluoroquinolones

Answer 42

Ciprofloxacin Ofloxacin Norfloxacin

Question 43

Third generation fluoroquinolones

Answer 43

Levofloxacin Sparfloxacin Grepafloxacin

Question 44

Fourth generation cephalosporins

Answer 44

Moxifloxacin Trovafloxacin Gemifloxacin Gatifloxacin

Question 45

SE of Zidovudine

Answer 45

Bone marrow suppression

Question 46

SE of Abacavir

Answer 46

Hypersensitivity

Question 47

SE of Didanosine

Answer 47

Pancreatitis

Question 48

SE of Stavudine, Zalcitabine

Answer 48

Peripheral neuropathy

Question 49

An antiviral that inhibits neuraminidase.

Answer 49

Oseltamivir Anti-influenza

Question 50

MOA of Interferon-a

Answer 50

Degrades viral RNA via activation of host cell RNAse (ribonuclease)

Question 51

Contraindications of Interferon-a

Answer 51

Autoimmune disease, hx of cardiac arrhythmias, and pregnancy

Question 52

DOC for pregnant px with malaria

Answer 52

Quinine

Question 53

Severe complication of P. Falciparum malaria characterized by intravascular hemolysis, massive hemoglobinuria, and acute renal failure.

Answer 53

Blackwater fever

Question 54

Antimalarial used in chloroquine resistant areas and an alternative to quinine in acute attacks of falciparum.

Answer 54

Mefloquine

Question 55

DOC for uncomplicated falciparum malaria in the Philippines

Answer 55

Co-artem Arthemeter + lumefantrine

Question 56

DOC for Asymptomatic intestinal infection of E.histolytica

Answer 56

Diloxanide furoate

Question 57

A tissue amebicide given only when Metronidazole could not be used

Answer 57

Emetine

Question 58

DOC for severe intestinal and extraintestinal amebiasis

Answer 58

Metronidazole

Question 59

DOC for prevention and treatment of pneumocystosis

Answer 59

Co- trimoxazole

Question 60

DOC for prophylaxis and treatment of Toxoplasmosis

Answer 60

Pyrimethamine-Sulfadiazine

Question 61

What are the major inhibitory neurotransmitters?

Answer 61

GABA | GLYCINE

Question 62

What are the major excitatory neurotransmitters?

Answer 62

Glutamate | Aspartate

Question 63

A short acting benzodiazepine

Answer 63

Midazolam

Question 64

Type of amnesia as a side effect of benzodiazepines

Answer 64

Anterograde amnesia

Question 65

What abnormal sleep pattern results from the use of Benzodiazepines?

Answer 65

Decrease REM sleep

Question 66

Benzodiazepine which is used as a date rape drug

Answer 66

Flunitrazepam

Question 67

Benzodiazepine that has the longest half life

Answer 67

Chlordiazepoxide HL 36-200hrs

Question 68

Shortest acting Barbiturate

Answer 68

Thiopental

Question 69

What changes in the brain are seen in Wernicke- Korsakoff syndrome?

Answer 69

Hemorrhagic necrosis of the mamillary bodies

Question 70

Drugs causing Hyperthyroidism

Answer 70

Clofibrate Amiodarone Methadone