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M1 - MCM Exam 1 > Basics and Reactions > Flashcards

Flashcards in Basics and Reactions Deck (17):
1

Enzyme uses Cooper (Cu) cofactor

Cytochrome C Oxidase - Accept electrons from cytochrome-c in the electron transport

2

Enzyme that uses Zinc (Zn) and Cooper (Cu)

Superoxide dismutase - antioxidant - binds the free ROS and RNS

3

Cytochrome C Oxidase cofactor and function

Accepts electrons from Cytochrome-C in the ETC

Uses Cooper (Cu) as a cofactor

4

What cofactor does Superoxide Dismutase require?

Cooper and Zinc

5

Enzyme that uses Iron (Fe) as a cofactor

Heme - helps bind O2 for transport

6

What cofactor is needed for Heme?

Iron

7

Enzyme the need Magnesium (Mg) as a cofactor

ATPase - hydrolyzes ATP to ADP and uses released energy to do mechanical energy

8

What cofactors do ATPase require?

Magnesium

9

Enzyme that needs Selenium (Se) cofactor

Glutathione peroxidase (antioxidant) - detoxifies H2O2

10

What cofactor does glutathione peroxidase need?

Serine

11

Explain action of Gastric Proton Pump

Proton pump (H+/K+ ATPase) pumps H+ out into the stomach and K+ comes into the parietal cells

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12

Competitive Inhibition

Resembles substrate

No effect on Vmax

Increase Km (increases the amount of substratae required to reach 1/2Vmax

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13

Noncompetitive Inhibition

Binds to an allosteric binding site

Can bind to ES complex and enzyme

Adding substrate can not overcome enzyme

Vmax - lowered

Km - unchanged (binding affinity is not effected)

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14

Uncompetitive Inhibitor

Binds to ES-complex

Vmax lowered

Km lowered by the same factor

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15

Chelating Agents

Substances that have a higher binding affinity and allows the metal ions to bind and be excreated

Ex. EDTA is used for lead poisoning

Lead diplaces Ca2+ in enzymes needed for biosynthesis

16

Isozymes

Same catalytic function

Can be used for biomarkers

17

Main BioMarker for Myocardial Infarction

cTn-1

Cardiac muscle troponin has 3 subunits and skeletal muscle troponin has 2 subunits