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Flashcards in BBB penetrability of Drugs Deck (4)
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1

Excellent with or without inflammation in the brain

Sulfonamides
Chloramphenicol
Trimethoprim
Metronidazole
Rifampicin
Isoniazid
Fluconazole
Flucytosine

2

Good only with inflammation

Penicillins
Cephalosporins- cefuroximes (2nd gen); 3rd gen parenteral (except cefoperazone); 4th gen imipenem, cilastatin
meropenem
Aztreonam
Ciprofloxacin
Vancomycin

3

Minimal or not good even with inflammation

Aminoglucosides- can pass through BBB in neonates because BBB is still immature
Tetracyclines
Lincosamides
Macrolides

4

No passage event with inflammation

Polymixins
1st and 2nd gen
cephalosporins
Amphotericin B