Mechanisms of antimicrobial resistance Flashcards Preview

Microbiology > Mechanisms of antimicrobial resistance > Flashcards

Flashcards in Mechanisms of antimicrobial resistance Deck (28)
Loading flashcards...
1

B-lactams

hydrolysis
mutant PBP

2

Tetracycline

Active efflux from the cell

3

Aminoglycosides

Inactivation by enzymes

4

Sulfonamides

Overproduction of target

5

Fluoroquinolones

Mutant DNA gyrase

6

Chloramphenicol

Reduced uptake into cell

7

Vancomycin

reporgramming of D-ala-D-ala

8

Quinupristin/dalfopristin

ribosomal methylation

9

Macrolides erythromycin

RNA methylation
drug efflux

10

When combined with the beta-lactamase inhibitor tazobactam, this penicillin possesses the broades antibacterial spectrum among its kind

Piperacillin

11

A 28 year old Caucasian male with cystic fibrosis developed Pseudomonas aeruginosa pneumonia. Sensitivity studies showed resistance to levofloxacin. Which of the following drug resistance mechanisms is responsible for this ?

alterations in the target enzymes (DNA gyrase and topoisomerase IV) and of changes in drug entry and efflux

12

Tetracycline resistance in gram + and gram - bacteria

active efflux of antimicrobial agent

13

Fluconaole resistance in candida spp

active efflux of antimicrobial agent

14

Resistance to multiple antibiotic classes in Pseudomonas aeuruginosa

Impermeability

15

Glycopeptide resistance in S. aureus

Impermeability

16

Aminoglycoside resistance in strict anaerobes

Impermeability - uptake requires O2 dependent transportern system

17

Aminoglycoside resistance in streptococci

Impermeability

18

meticillin/flucloxacillin, resistance in MRSA

Altered penicillin -binding protein

19

S. pneumoniae and Neisseria meningitidis resistance in penicillin

Altered penicillin -binding protein

20

glyopeptide resistant Enterococci

Altered peptidolgycan

21

Rifampicin resistance in Mycobacterium tuberculosis

RNA polymerase mutation

22

Ciprofloxacin resistance in enterobacteriacea

DNA gyrase mutation

23

Resistance to protein synthesis inhibitors (macrolides, lincosamides, aminoglycosides, rifampicin, linezolid)

ribosomal protein gene mutations

24

trimethoprim resistance is due to

dihydrofolate reducatase mutations

25

Echinocandin resistance in cryptococcus spp.

Absence of antimicrobial target

26

trimethoprim resistance is due to

Overproducion of dihydrofolate reductase

27

resistance of Staph aureus to penicilllin

penicillinase - degradation of antimicrobial agent

28

Enterobacteriaceae

enzymatic degradation of antimicrobial agent
extended spectrum beta lactamase producing enterobacteriaceae
AmpC Beta lactamases (cephalsporinases) enterobacteriaceae