Behavioral Science - Schizophrenia Flashcards Preview

MS 2 - Unit 3 > Behavioral Science - Schizophrenia > Flashcards

Flashcards in Behavioral Science - Schizophrenia Deck (39):
1

Psychosis is a hallmark symptom of what psychiatric disorder?

Schizophrenia
--Hallucinations, delusions, abnormalities in thought process/organization

Psychosis CAN occur in other disorders is bipolar disorder, substance abuse, delirium, depression

2

What are the symptoms of psychosis?

Illusion
Hallucinations
Ideas of reference
Delusions
Loss of ego boundaries

3

What is echolalia?

Repeating the statements of others, associating words by sound

Symptom of psychosis

4

Alogia
Echolalia
Thought Blocking
Neologisms
Circumstantiality
Tangentiality
Loose associations

These are characteristics of:

Psychosis

5

The diagnostic symptoms for schizophrenia are:

Part A symptoms:

1. Delusions
2. Hallucinations
3. Grossly disorganized or catatonic behavior
4. Negative symptoms (flat affect, alogia, avolition
5. Disorganized speech

**2 or more, each present for a significant portion of time during a 1-month period

6

What is the DSM criteria for schizophrenia?

Characteristic symptoms;
Social and occupational dysfunction (symptoms are affecting your life);
Continuous signs of disturbance present for 6 months with at least 1 month of active symptoms;
Can't be due to other mood disorder or medical condition

7

Positive symptoms of schizophrenia are:

Delusions
Hallucinations
Agitation
Talkativeness
Thought disorder

respond well to antipsychotics

8

Negative symptoms of schizophrenia are often mistaken for:

Depression

Lack of motivation
Social withdrawal
Flattened affect/emotion
Cognitive disturbances
Poor grooming
Impoverished speech

sometimes a better response with atypical antipsychotics

9

What is the residual phase of schizophrenia?

Period between psychotic episodes, in touch with reality but does not behave normally

10

What is the prodromal phase of schizophrenia?

Prior to first psychotic break - several months to a year or two

Anxiety and depression are common;
Avoiding social activities;
Quiet and passive or irritable;
Sudden interest in religion;
Physical complaints

11

What is the age of onset of schizophrenia?

15-25 in men
25-35 in women

1:1 incidence in men and women

12

Women with schizophrenia have a greater risk of what complication?

Tardive dyskinesia (bc of D2 receptor drug blockage)

13

Third trimester maternal use of diuretics is associated with what greater risk?

Schizophrenia

14

Negative symptoms in schizophrenia are from

Hypofrontal frontal lobes
Cold dorsolateral PFC;
Decreased use of glucose

15

Lateral and third ventricle enlargement is seen in what psychiatric disorder?

Schizophrenia

Along with changes in brain density, decreased volume of hippocampus, amygdala and parahippocampal gyri

16

What happens if dopamine is blocked in the brain, for example, in the mesolimbic pathway, and then there is subsequently less dopamine in the tuberoinfundibular pathway?

Increase in prolactin secretion when DA is low

17

What are the BRAIN goals of schizophrenia treatment?

SLOW mesolimbic pathway (positive symptoms);
INCREASE mesocortical pathway (negative symptoms);
HAVE NO EFFECT ON tuberoinfundibular pathway and nigrostriatal pathway

18

What metabolite of dopamine is found in elevated levels in patients with schizophrenia?

Homovanillic acid

19

What is the leading hypothesis behind schizophrenia?

Glumate --> dopamine

20

What is GLU-GABA-GLU-DA ?

Normal functioning

21

What is GLU-GABA-GLU-GABA-DA?

Normal functioning

Hyperactivate second GLU - hypofunctioning --> negative symptoms

22

What is schizophreniform disorder?

1-6 months of symptoms

23

What is schizoaffective disorder?

Schizophrenia + mania/depression

24

What is brief psychotic disorder?

1-29 days of schizophrenia symptoms

25

All effective antipsychotics block _____ in the mesolimbic dopamine path.

D2

26

Haloperidol and Chlorpromazine are what kinds of drugs?

Traditional, typical first generation antipsychotics
--more side effects in nigrostriatal and tuberoinfundibular pathways

27

Use: Clozapine

Atypical antipsychotic;
first line for schizophrenia;
5HT2a blockade allows dopamine to move more freely in the nigrostriatal path

28

Use: Risperidone

Atypical antipsychotic;
first line for schizophrenia;
5HT2a blockade allows dopamine to move more freely in the nigrostriatal path --> less neurological side effects

29

Use: Paliperidone

Atypical antipsychotic;
first line for schizophrenia;
5HT2a blockade allows dopamine to move more freely in the nigrostriatal path --> less neurological side effects

30

Use: Olanzapine

Atypical antipsychotic;
first line for schizophrenia;
5HT2a blockade allows dopamine to move more freely in the nigrostriatal path --> less neurological side effects

31

Use: Quietapine

Atypical antipsychotic;
first line for schizophrenia;
5HT2a blockade allows dopamine to move more freely in the nigrostriatal path --> less neurological side effects

32

Use: Ziprasidone

Atypical antipsychotic;
first line for schizophrenia;
5HT2a blockade allows dopamine to move more freely in the nigrostriatal path --> less neurological side effects

33

Use: Aripiprazole

Atypical antipsychotic;
first line for schizophrenia;
5HT2a blockade allows dopamine to move more freely in the nigrostriatal path --> less neurological side effects

34

Use: Asenapine

Atypical antipsychotic;
first line for schizophrenia;
5HT2a blockade allows dopamine to move more freely in the nigrostriatal path --> less neurological side effects

35

Use: Iloperidone

Atypical antipsychotic;
first line for schizophrenia;
5HT2a blockade allows dopamine to move more freely in the nigrostriatal path --> less neurological side effects

36

Use: Lurasidone

Atypical antipsychotic;
first line for schizophrenia;
5HT2a blockade allows dopamine to move more freely in the nigrostriatal path --> less neurological side effects

37

What second generation antipsychotics are available as shots?

Risperidone
Paliperidone
Aripiprazole

decrease relapse

38

What psychotherapy is helpful in schizophrenia treatment?

CBT
Family therapy
Peer and mentor groups

39

Neurotransmitter abnormalities in schizophrenia include:

Excess dopamine, serotonin, glutamate, norepinephrine

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