Flashcards in Benzo and Mood Stabilizers Deck (61)
What are the properties of benzos?
What do anxiolytic agents do?
Reduces anxiety and produces a calming effect with little effect on motor and mental functions
Decreases activity, moderates excitement, and calms
What do hypnotic agents do?
Produces drowsiness and facilitates the onset and maintenance of a state of sleep
How is GABA modulated?
Allosterically modulated by a number of nearby receptors
What is the MOA for benzos?
Increase the frequency of Cl channel opening through allosteric modulation, allowing influx of Cl ions
How do benzos enhance GABA's effect?
Allosterically modulates the GABA A receptor binding site, which in turn modulates the chloride channel
What are the most common SEs of typical benzo use?
What are the side effects of an overdose of benzos?
What are the contraindications/wanrings to benzos?
Acute narrow angle glaucoma
Severe respiratory insufficiency
Use of concomitant CNS depressants
Patients with h/o drug dependence
Falls and mental alertness
What are benzo withdrawal symptoms?
What is considered long term use of benzoes?
If a patient is using benzos for at least 2-6 months, what is the tapering schedule for discontinuation?
Slow taper by decreasing dose 10-25% every 4 weeks
What part of benzo withdrawal is paramount?
Patient education and careful monitoring
What is the MOA of anxiolytics?
5-HT1a partial agonist
What is an anxiolytic?
What is the onset of buspar?
Delayed (2+ weeks)
Don't use PRN
What is Buspar approved for?
Approved for GAD
What is Buspar off label for?
Which drugs are key mood stabilizers?
Which drugs are other agents that work as mood stabilizers?
Which mood stabilizer were not shown to have an increased risk of suicidality?
Which mood stabilizers are NTIs?
What is lithium's mechanistic consideration?
Alter cation transport
Effects on second messenger systems
How is lithium adjusted?
CrCl < 50 (but must be stable)
When are lithium troughs drawn?
8-12 hours post dose
What is the therapeutic range for lithium in acute mania?
What is the therapeutic range for lithium for prophylaxis?
What baseline labs must be taken before lithium treatment?
BUN, SCr, Thyroid function tests, ECG if patient > 40 or hx, CBC
What are the most common SE of Lithium?