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Flashcards in MDD Deck (65)
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1

What is MDD characterized by?

Persistent low mood
and
Lack of positive affect
Anhedonia (Loss of interest in usually pleasurable activities) that is different from patient's usual self
and
Causes significant distress or impairment for 2+ weeks

2

Which sex is MDD more common in?

Women > men

3

What does MDD co-occur with?

Other psychiatric and medical conditions

4

What does MDD contribute to?

Suicide - must assess

5

What does MDD impact?

Functioning and ability to work

6

What is MDD partially due to?

Genetics
Stress
Environment (biopsychosical model)

7

What hypothesis does MDD therapy focus on?

"Monoamine hypothesis"
or
"Biogenic amine hypothesis"

8

What is the monoamine hypothesis?

Deficiency/underactivity in serotonin, NE, DA, GABA, tryptophan, somatostatin, and thyroid hormones have all been impacted in causing MDD or depression

9

What are the RFs for MDD?

FH
Other psychiatric illness
Stress
Female
Meds
Illness

10

What meds cause MDD?

Clonidine
Oral contraceptives
Corticosteroids
AEDs
Antipsychotics
Varenicline
Benzo
EtOH
Opioids

11

What is the first step in treating MDD?

Treating or removing underlying cause

12

How long will sx develop in MDD?

days-weeks

13

What is the onset of MDD?

Mid-20s

14

Is MDD recurrent or one time?

Recurrent

15

Are recurrent episodes of MDD variable or consistent?

Variable

16

When are longer periods of remission most common in MDD?

Early in course

17

What is a predictor or MDD persistence?

Severity of initial major depressive episode

18

Which assessments are used in MDD?

PHQ-9
HAM-D

19

What is PHQ-9 used for?

To screen for and diagnose depression
Can be completed in minutes

20

What is the HAM-D used for?

Monitoring
Decreasing score = improvement

21

How many sx must be present for how long in MDD?

5+ sx (at least one of the following: depressed mood or loss of interest/pleasure)
During the same 2 week period

22

What are the sx of MDD?

SIG E CAPSL
Sleep (insomnia/hypersomnia)
Interest (loss of interest/pleasure)
Guilt (feelings of worthlessness or excessive/inappropriate guilt)
Energy (fatigue/loss of energy)
Concentration
Appetite (change in appetite/weight)
Psychomotor
Suicidal thoguhts
Low mood

23

What variation of MDD is experienced in elderly?

"pseudo-dementia"

24

What types of physical complaints are common?

Somatic - involves having a significant focus on physical sx to the point that it causes major distress and problems functioning

25

What is persistent depressive disorder?

2 years of impaired functioning secondary to MDD sx (5 or less)

26

What is considered a response to therapy of MDD?

50% reduction of sx

27

What is partial response to therapy of MDD?

Less than 50% reduction of sx

28

What is considered MDD remission?

A period of 2 or more months w/no sx
1-2 sx of mild degree
Primary goal of treatment

29

What is considered MDD recovery?

Sustained remission lasting > 6 months

30

What is considered MDD relapse?

Return of manifestations of a disease