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Biochem Prelim 2nd Sem > Beta Oxidation Of Fatty Acids > Flashcards

Beta Oxidation Of Fatty Acids Flashcards

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0
Q

Beta oxidation location

A

Inner mitochondria or matrix

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1
Q

Principals means by which FA oxidized to forms ATPs

A

Beta oxidation

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2
Q

Process of beta oxidation

A

Removal of 2 carbon atoms at a time

Removals start at COOH (carboxyl end)

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3
Q

Major end product of beta oxidation

A

Acetyl CoA

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4
Q

Very first reaction of beta oxidation takes place in the

A

Cytoplasm

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5
Q

The chemical reactions in beta oxidation are usually opposite to

A

Lipogenisis

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6
Q

Addition of 2 carbons at a time

A

Lipogenesis

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7
Q

Lipogenesis location

A

Cytoplasm

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8
Q

Lipogenesis

Substrate

A

Acetyl CoA

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9
Q

All even number fatty acids the end products

A

Acetylcoa

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10
Q

If odd number fatty acids

A

It will undergo usual beta oxidation but when you already have 5 remaining carbon atoms minus 2 3 carbon atoms, profunyl CoA, then methyl malonyl coa, then succinyl coa

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11
Q

3 carbon atom molecule

A

Profunyl coA

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12
Q

Intermediate of krebs cycle

A

Succinyl coa

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13
Q

Reaction 1

A

Free fatty acid +CoA + ATP to

Fatty Acyl CoA

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14
Q

Reaction 1 location

A

Cytoplasm

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15
Q

Reaction 1 enzyme

A

Thiokinase (Acyl CoA synthetase)

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16
Q

ATP reaction

ATP to AMP + PPI + Heat

Enzyme

A

Pyrophosphate

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17
Q

ATP reaction

PPi to Pi + Pi + heat
Enzyme

A

Pyrophosphatase

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18
Q

Reaction 2

A

Carnitine transport system

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19
Q

Reaction 2.1

A

Fatty Acyl CoA + Carnitine to

Acylcarnitine (Fatty Acyl Carnitine Complex)

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20
Q

Reaction 2.1

Enzyme

A

Carnitine Palmitoyl Transferase 1

Rate limiting enzyme

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21
Q

Location of the enzyme in reaction 2.1

A

Outer mitochondrial membrane

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22
Q

Enzyme in reaction 2.1 inhibited by

A

Malonyl CoA

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23
Q

Intermediate in extramitochondrial lipogenesis

A

Malonyl CoA

Kaya hindi pwedeng magkasbay ang lipogenesis at beta oxydation

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24
Reaction 2.1 Location of the reaction:
Intermitochondrial space
25
Rate limiting step and commited step
Reaction 2.1
26
Reaction 2.2
Acylcarnitine goes | Inside the super inside of the mitochondria (mitochondrial matrix)
27
Reaction 2.2 Enzyme
Carnitine Acylcarnitine Translocase
28
Reaction 2.2 Location of the enzyme
Inner mitochondrial membrane
29
Reaction 2.2 Type of enzyme
Co transporter | Anti port
30
2 molecule of acylcarnitine transported to the mitochondrial matrix
Co transporter
31
1 molecule of carnitine transported to the mitochondrial intermembrane space
Anti port
32
Reaction 2.2 Location of reaction
Intermitochondrial space to mitochondrial matrix
33
Reaction 2.3
Acylcarnitine to | Acyl CoA + Carnitine
34
Reaction 2.3 Acyl CoA goes to
Reaction 3.1
35
Reaction 2.3 Carnitine transported to
Back to intermitochondrial space
36
Reaction 2.3 Enzyme
Carnitine palmitoyl transferase 2
37
Reaction 2.3 Location of enzyme
Inner mitochondrial matrix
38
Reaction 2.3 Location of reaction
Mitochondrial matrix
39
Reaction 2.4
Carnitine goes back to the intermitochondrial space
40
Reaction 2.4 Enzyme
Carnitine Acylcarnitine translocase
41
Carnitine synthesized from
Lysine | Methionine
42
Sufficient doses of carnitine
Enough substance to proceed to beta oxidation
43
More carnitine
More FA oxidized | Less FA converted to fats
44
Reaction 3
Oxidative step
45
Reaction 3 Location
Mitochondrial matrix
46
Reaction 3.1
1st oxidative step
47
Reaction 3.1 1st oxidative step
Fatty acyl CoA to | Unsaturated Acyl CoA
48
Reaction 3.1 Enzyme
Acyl CoA dehydrogenase
49
Reaction 3.1 Coenzyme
FAD
50
Reaction 3.2
Hydration step
51
Reaction 3.2hydration step
Unsaturated acyl CoA to | Beta Ketoacyl CoA
52
Reaction 3.2 hydration step Enzyme
Enoyl CoA Hydratase
53
Reaction 3.2 hydration step Reaction process
Water added
54
Reaction 3.3
2nd oxidative step
55
Reaction 3.3 2nd oxidative step
Beta Hydroxyacyl CoA to | Beta Ketoacyl CoA
56
Reaction 3.3 2nd oxidative step Enzyme
Beta hydroxyl CoA dehydrogenase
57
Reaction 3.3 2nd oxidative step Coenzyme
NAD
58
In reaction 3 how many ATP produced per cycle?
5ATP 2 from FADH 3 from NADH
59
Reaction 4
Thiolysis
60
Reaction 4 Thiolysis
Beta Ketoacyl CoA to | Fatty Acyl CoA + Acetyl CoA
61
Reaction 4 Thiolysis Fatty acyl CoA goes to
Reaction 3 hanggang maubos ito
62
Reaction 4 Thiolysis Acetyl CoA goes to
Lipogenesis
63
Reaction 4 Thiolysis Enzyme
Beta Keto Thiolase
64
Other types of fatty acid oxidation
Peroximal oxidation Alpha oxidation Omega oxidation
65
Oxidation of VERY LONG CHAIN FATTY ACIDS (C20-C22) | Modified form of Beta Oxidation
Peroximal Oxidation
66
Peroximal Oxidation End products
Acetyl CoA | H2O2 (peroxide)
67
Removes ONE carbon atom at a time starting from COOH end Does not generate high energy phosphate CoA not required
Alpha Oxidation
68
Minor pathway | Cytochorme P450 involved
Omega oxidation
69
Omega oxidation | Location
Endoplasmic Reticulum
70
Episodic periods of hypoglycemia | Decreased gluconeogenesis
Carnitine deficiency
71
Hypoglycemia Affected organ is liver Inherited
Deficiency of Carnitine Palmitoyl CoA transferase 1
72
Affects the skeletal muscles | Necrosis with myoglobinuria
Deficiency of carnitine palmitoyl CoA transferase 2
73
Defectin alpha oxidation | Accumulation of Phytanic Acid
Refsum's disease
74
Caused by eating unripe fruit (akee tree) | Fruit with hypoglycin
Jamaican vomiting sickness
75
Inactivates. Medium and short chain Acyl CoAdehydrogenase | Beta oxidation inhibited
Hypoglycin
76
Absence of peroxisomes in the tissue Accumulation of Polyenoic Acids (C26-C38) in the brain tissue Impaired bile acid and other lipid synthesis
Zellweger's cerebrohepatorenal syndrome

Biochem Prelim 2nd Sem (13 decks)

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