Triacylglycerol Flashcards
(35 cards)
Increased synthesis and storage of TAG could lead to
Obesity
Chief storage form of energy in thebody
TAG
Old man face
Skin and Bony Appearance
Due to deprivation of calorie
Marasmus
In 70 kgman, how many kilocalories
135, 000 kilocalories
Normal body mass index
18-24
Grade 1 obesity
25-30
Clinical obesity
Greater than 30. Mass index
Grade 3 obesity
Morbid obesity
Lipoproteins that have TAG as there lipid component
Chylomicron
VLDL
Cause of abnormal lipoprotein disorders
Impaired metabolism of TAGs
Deficiency of Lipoprotein Lipase
Disease associated with obesity
4Fs of gall bladder disease
Fat
Female
Forty
Fertile
Location of TAG synthesis
SER
Three organs that are active in TAG synthesis
Adipose tissue
Liver
Intestines
TAG synthesis reaction 1
Activation of Fatty acids
TAG synthesis
Reaction 1 activation of Fatty acids
Fatty acids + ATP to
Fatty acids CoA + AMP + PPI
TAG synthesis
Reaction 1 enzyme
Thiokinase/ Fatty Acyl CoA
Magiging activated ang fatty acid by incorporating it to
CoA in the presence of thiokinaseor. Fatty acyl synthetase
Eg. Palmitic acid when activated it becomes palmitoyl CoA
TAG synthesis
Reaction 2
Phosphorylation of Glycerol
TAG synthesis reaction 2 Phosphorylation of Glycerol
Glycerol to
Glycerol 3 phosphate
TAG synthesis
Reaction 2 enzyme
Glycerokinase
Low activity or absent sa adipose tissue and skeletal muscle ang Glycerokinase, so saan nakukuha ang Ito?
Dihydroxyacetone phosphate
TAG synthesis
Reaction 3
Combination of reactants
TAG synthesis
Reaction 3 combination of reactants
Glycerol 3 Phosphate (from reaction 2) + 2 Fatty Acyl CoA (from reaction1) to
Phosphatidic acid
TAG synthesis
Reaction 3 enzyme
Acyl Transferase