Bilirubin Metabolism Flashcards Preview

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Flashcards in Bilirubin Metabolism Deck (18)
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1

Bilirubin is a by product of what?

Red blood cell breakdown in the spleen

2

Old red blood cells >? days are broken down to release what two things?

120
Heme and globin

3

The heme is further broken down the release what?

Iron and biliverdin

4

Biliverdin is converted into what? How is it carried in the blood?

Bilirubin
Attached to albumin

5

Bilirubin attached to albumin is insoluble to what? Soluble in what?

Water (indirect) - insoluble
Lipids - soluble

6

The Bilirubin is transported to the liver where it is conjugated with a __________ by _______?

glucuronide
UDPG transferase

7

Conjugation of the Bilirubin does what to it?

Renders it into a water-soluble state

8

Conjugated (direct) bilirubin is secreted into what and stored where?

biliary tract
gallbladder

9

Bile is bilirubin plus what?

Bile salts

10

Bile does what to fat?

saponifies it (like soap) rendering it more easily digested by pancreatic lipase

11

The bilirubin in the gut is converted to what by bacteria?

urobilinogen

12

What happens to 90% of the urobilinogen?

Absorbed into the blood stream

13

5% of the urobilinogen does what?

Is excreted in the urine where it is covered to urobilin

14

What colors the urine yellow?

urobilin

15

10% of the urobilinogen in the gut is converted into what?

stercobilinogen

16

Stercobilinogen is oxidized into what?

Stercobilin

17

What colors the stool brown?

stercobilin

18

What percentage of the bile salts are reabsorbed and sent back to the liver (enterohepatic circulation)?

95%