Flashcards in Bilirubin Metabolism Deck (18)
Bilirubin is a by product of what?
Red blood cell breakdown in the spleen
Old red blood cells >? days are broken down to release what two things?
Heme and globin
The heme is further broken down the release what?
Iron and biliverdin
Biliverdin is converted into what? How is it carried in the blood?
Attached to albumin
Bilirubin attached to albumin is insoluble to what? Soluble in what?
Water (indirect) - insoluble
Lipids - soluble
The Bilirubin is transported to the liver where it is conjugated with a __________ by _______?
Conjugation of the Bilirubin does what to it?
Renders it into a water-soluble state
Conjugated (direct) bilirubin is secreted into what and stored where?
Bile is bilirubin plus what?
Bile does what to fat?
saponifies it (like soap) rendering it more easily digested by pancreatic lipase
The bilirubin in the gut is converted to what by bacteria?
What happens to 90% of the urobilinogen?
Absorbed into the blood stream
5% of the urobilinogen does what?
Is excreted in the urine where it is covered to urobilin
What colors the urine yellow?
10% of the urobilinogen in the gut is converted into what?
Stercobilinogen is oxidized into what?
What colors the stool brown?