BIO CHEM 5 Flashcards by ROLLIE ESTEVES

Which of the following is not one of the states of lipids?

Para crystalline state
Liquid ordered state
Liquid disordered state
Crystalline state

Crystalline state

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Which of the following arrangement based on the increasing order of motion is correct?

Uncatalysed transverse motion, transverse diffusion catalyzed by flippase, uncatalysed lateral diffusion

Uncatalysed lateral diffusion, uncatalysed transverse motion, transverse diffusion catalyzed by flippase,

Uncatalysed transverse motion, uncatalysed lateral diffusion, transverse diffusion catalyzed by flippase

Transverse diffusion catalyzed by flippase, uncatalysed lateral diffusion, uncatalysed transverse motion,

Uncatalysed transverse motion, transverse diffusion catalyzed by flippase, uncatalysed lateral diffusion

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Movement of phospholipids from side to side is called

Facilitated diffusion
Lateral diffusion
Transverse diffusion
Simple diffusion

Lateral diffusion

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Movement of phospholipids to opposite sides is called

Facilitated diffusion
Lateral diffusion
Transverse diffusion
Simple diffusion

Transverse diffusion

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Trans bilayer diffusion is also called

Facilitated diffusion
Lateral diffusion
Flip flop
Simple diffusion

Flip flop

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Which of the following is an example of heterodimeric protein?

Integrin
Antibodies
Receptor tyrosine kinase
G-protein coupled receptor

Integrin

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Which of the following is an example of peripheral membrane protein?

Insulin receptor
Glycophorin
Integrin
Glycolipid transfer proteins

Glycolipid transfer proteins

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Which of the following proteins does not function in cell- cell interaction?

Integrin
Cadherin
N-CAM
Cytochrome c

Cytochrome c

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Which of the following integral membrane protein is a special class of membrane rafts?

Caveolin
Integrin
Cadherin
Selectin

Caveolin

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Which of the following is one of the family of immunoglobin like proteins that mediate Ca2+?

N-CAM
Integrin
Cadherin
Selectin

N-CAM

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Erythrocyte glucose transporter is an example of

Ion driven active transport
Facilitated diffusion
Active transport
Simple diffusion

Facilitated diffusion

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Which out of the following is not a mediated transport?

Facilitated diffusion
Primary active transport
Secondary active transport
Simple diffusion

Simple diffusion

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Na+ glucose transporter is an example of

Symport
Antiport
Facilitated diffusion
ATP driven active transport

Symport

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Which of the following is energy independent?

Active transport
Primary active transport
Secondary active transport
Passive transport

Passive transport

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Semipermeable membrane allows

Solute to pass
Solution to pass
Solvent to pass
Proteins to pass

Solvent to pass

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When does saturation occur?
`
When molecules are moved by the use of vesicles

When the energy from a high-energy bond is required to move molecules

When a group of carrier proteins is operating at its maximum rate

When a carrier molecule has the ability to transport only one molecule or a group of closely related molecules

When a group of carrier proteins is operating at its maximum rate

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In which of the following means of transport a cell expels large molecules out of it?

Phagocytosis
Exocytosis
Endocytosis
Diffusion

Exocytosis

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HCO3– – Cl– transporter is an example of

a. Uniport
b. Antiport
c. Symport
d. Facilitated diffusion

Antiport

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Which of the following transports only one kind of substrate?

Uniport carriers
Symport carriers
Antiport carriers
Membrane proteins

Uniport carriers

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Which of the following induces conformational change in protein?

Uniport
Symport
Antiport
Facilitated diffusion

Antiport

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The information which is represented by a signal is detected by specific receptors and converted to a cellular response; this conversion is called

Signal amplification
Signal transversion
Signal transduction
Signal integration

Signal integration

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Signal molecule fits the binding site on its complementary receptor called as

Specificity
Amplification
Integration
Cooperativity

Specificity

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Number of affected molecules increases geometrically in an enzyme cascade in

Specificity
Amplification
Adaptation
Integration

Amplification

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Receptor is removed from cell surface in

Specificity
Amplification
Adaptation
Integration

Adaptation

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Regulatory outcome results from integrated input from both receptors is in Specificity Amplification Adaptation Integration

Integration

Acetylcholine receptor ion channel is an example of Gated ion channel Receptor enzymes Membrane protein Nuclear protein

Gated ion channel

How many types of signal transducers are there? 3 4 5 6

Which of the following is a nuclear receptor protein? Steroid receptor Adhesion receptor Serpentine receptor Receptor with no intrinsic enzyme activity

Steroid receptor

Receptor proteins that indirectly activate enzymes that generate intracellular second messengers are Steroid receptors Serpentine receptors Adhesion receptors Receptor enzymes

Serpentine receptors

Insulin receptor is an example of Steroid receptors Serpentine receptors Adhesion receptors Receptor enzymes

Receptor enzymes

Which of the following statements is true about transmembrane electrical potential? The chemical gradient drives Cl– and K+ inwards The electrical gradient drives Na+ and Ca2+ inwards The chemical gradient drives Na+ and Ca2+ inwards The chemical gradient drives Cl– and K+ outwards

The chemical gradient drives Na+ and Ca2+ inwards and K+ outward

Nicotinic acetylcholine receptor is an example of Ligated gated receptor channel Serpentine receptors Adhesion receptors Receptor enzymes

Ligated gated receptor channel

Which of the following are intracellular second messengers? Acetylcholine Glycine IP3 Glutamate

IP3

The receptor channels for which of the following are gated by extracellular ligands? Glycine IP3 cAMP cGMP

Glycine

Which of the following statements is false about a ligand-gated ion channel receptor? They are present in the cell membrane They consist of five glycoproteins Differences in membrane potential affect whether the channel receptors are open or close Neurotransmitters can act as the chemical messengers for these channels

Differences in membrane potential affect whether the channel receptors are open or close

Voltage regulation means Na+/K+ pumps controls potential Unless the voltage is regular gates will not respond Oscilloscope only can control potential With changes in the membrane potential voltage gated ion channels open and close

With changes in the membrane potential voltage gated ion channels open and close

Depolarization and repolarization changes that occur during the action potential are produced by Negative feedback loops Carrier mediated transport Simple diffusion of ions down their concentration gradient Active transport pumps along the neuron membrane

Active transport pumps along the neuron membrane

Diffusion of K+ out of the cell makes the inside of it less positive, or more negative and acts to restore the original resting membrane potential. This process is called Repolarization Depolarization Hyperpolarization Overshoot

Repolarization

Which of the following statements about action potential is false? Na+/K+ pumps are directly involved in creating the action potential Na+ and K+ concentrations are not significantly changed during an action potential This includes both positive and negative feedback loops Only a relatively small number of Na+ and K+ actually diffuse across the membrane

Na+ and K+ concentrations are not significantly changed during an action potential

Which out of the following is not a neurotransmitter? Noadrenaline Cyclic AMP Dopamine Acetyl choline

Cyclic AMP

SH2 domain specifically binds to GDP Ca2+ Phosphorylated tyrosine residues Phosphorylated serine residues

Phosphorylated tyrosine residues

cAMP and cGMP are derived from ATP and GTP by the actions of guanylate cyclase and adenylate cyclase respectively ATP and GTP by the actions of adenylate cyclase and gualnlate cyclase respectively GTP and ATP by the actions of adenylate cyclase and guanylate cyclase respectively None

ATP and GTP by the actions of adenylate cyclase and gualnlate cyclase respectively

Which of the following is false about phosphorylation by IRS on serine residue? It is an inhibitory phosphorylation It is molecular mechanism for insulin resistance It increases insulin levels Target tissues fail to respond to circulating insulin

It increases insulin levels

The enzyme activated by cyclic AMP, passing on the hormonal signal is Protein kinase B Protein kinase A Protein kinase C G protein receptor kinase

Protein kinase A

Protein kinase ERK is activated by phosphorylation of Only Thr Only Tyr Both Thr and Tyr Only Ser

Both Thr and Tyr

Activation of guanylyl cyclase produces Guanosine 3’, 5’-cyclic monophosphate Guanosine 2’, 5’-cyclic monophosphate Guanosine 4’, 5’-cyclic monophosphate Guanosine 1’, 5’-cyclic monophosphate

Guanosine 3’, 5’-cyclic monophosphate

cGMP-dependent protein kinase is also called Protein kinase B Protein kinase A Protein kinase G Protein kinase C

Protein kinase G

Which of the following is not responsible of producing diarrhea? Elevation in [cGMP] Increase in Cl– secretion Decrease in reabsorption of water by the intestinal epithelium Decrease in Cl– secretion

Decrease in Cl– secretion

Which of the following is a short-lived messenger that acts by stimulating a soluble guanylyl cyclase, raising [cGMP] and stimulating PKG? NO NO2 NO3– N2O

50. Ras protein is a G-protein switch Small monomeric GTPase switch protein Serine-threonine kinase Tyrosine kinase

Small monomeric GTPase switch protein

Which out of the following statements is true about G-protein couple receptors? The N-terminal chain is extracellular and C-terminal chain is intracellular It contains 5 trans-membrane hydrophobic sections There are more extracellular loops than intracellular loops The binding region for G-protein involves 2 extracellular loops

The N-terminal chain is extracellular and C-terminal chain is intracellular

Which of the following is not a G-protein coupled receptor? Glycine receptor Adrenergic receptor Glutamate receptor Muscarinic receptor

Glycine receptor

Protein kinase A is Completely inhibited by cyclic AMP Allosterically activated by cyclic AMP Affected by cyclic AMP only under unusual circumstances Activated by covalent binding of cyclic AMP

Allosterically activated by cyclic AMP

Which out of the following is not involved in signal transduction by β-adrenergic receptor pathway? GTP ATP cAMP cGMP

cAMP

Which of the following catalyzes the cutting of PIP2 into 2 moles of IP3 and diacylglycerol in cell signaling? Phosphokinase C Phospholipase C Lipokinase Phosphodiesterase C

Phospholipase C

The binding of ligands to many GPCRs leads to Decrease in concentration of certain intracellular signal molecules called second messengers Increase in concentration of certain intracellular signal molecules called second messengers Decrease in concentration of certain extracellular signal molecules called first messengers Increase in concentration of certain extracellular signal molecules called first messengers

Decrease in concentration of certain intracellular signal molecules called second messengers

A hormone or ligand can be considered as First messenger Second messenger Third messenger Fourth messenger

First messenger

Which of the following serves as a neurotransmitter in adrenergic neurons? Serotonin Epinephrine Dopamine Histamine

Epinephrine

Which second messenger signals the release of Ca+2 from endoplasmic reticulum? IP3 1,2 diacyl glycerol cAMP cGMP

IP3

GPCR is comprised of 7 transmembrane helices 8 transmembrane helices 9 transmembrane helices 10 transmembrane helices

7 transmembrane helices

The specificity of signaling pathways does not include Migration of signal proteins into membrane rafts Assembly of large multiprotein complexes Phosphorylation of target proteins at Ser, Thr/Tyr residues Flippase-catalyzed movement of phospholipids from the inner to the outer leaflet

Flippase-catalyzed movement of phospholipids from the inner to the outer leaflet

Which of the following directly phosphorylate tyrosines to start a kinase protein enzymatic cascade? Receptor tyrosine kinase Receptor guanylyl cyclases Receptor serine kinase Receptor threonine kinase

Receptor tyrosine kinase

PTB domains bind to Phosphorylated tyrosine Phosphoryated threonine Phosphorylated serine Phosphorylated cysteine

Phosphorylated tyrosine

Scaffold protein in insulin signal transduction KSR IRS-1 MEKK1 AKAP

IRS-1

Which of the following is involved in extrinsic cell death pathway? Heterotrimeric G protein complex TRADD IRS-1 Protein-kinase A

TRADD

Which of the following converts GTP to cGMP to start its enzymatic cascade? Receptor guanylyl cyclase Receptor adenylyl cyclase Calmodulin Protein kinase-A

Receptor guanylyl cyclase

Which of the following are stimulated to become membrane associated upon binding of insulin to the insulin receptor? PH-domain PTB SH3 SH2

PH-domain

Which of the following is involved in phospho-tyrosine binding? SH2 SH3 PTB PH

SH2

Which of the following is involved in proline rich motif binding? SH2 SH3 PTB PH

SH3

Which of the following is not a downstream component? Ras MEK ERK PIP3

PIP3

Which of the following statements about Arabidopsis is not true? In Arabidopsis, CTR-1 Ser/Thr protein kinase is activated by ethylene Activation of MAPK cascade EINI activation Synthesis of ERF1 transcription factor

In Arabidopsis, CTR-1 Ser/Thr protein kinase is activated by ethylene

The 2-component system drives bacterial chemotaxis by coupling autophosphoryaltion of which receptor to phosphorylation of respective regulatory protein? His kinase Adenylyl cyclase Guanylyl cyclase None

His kinase

Bacteria do not have which of the following receptors Adhesion receptors Nuclear steroid receptors Membrane proteins GPCR

Nuclear steroid receptors

A factor involved in regulating the fate of stem cells in plant development Adrenaline Epinephrine Thyroid stimulating hormone CLV1

CLV1

The peptide trigger for the self-incompatibility response that prevents self-pollination Salicylic acid Jasmonates Brassinosteroids Plant peptide hormones

Brassinosteroids

Autophosphorylation is done on His residues Ser/Thr residues Cys residues Lys residues

Ser/Thr residues

In Arabidopsis flg22 binds to FLS2 LPS BAK1 MAPK

FLS2

Transcription factor in plants is Serine Threonine WRKY22/29 Leucine

WRKY22/29

Negative regulator of ethylene response LPS CTR1 BAK1 MAPK

CTR1

ERF1is a Translation terminating factor Positive regulator Translation promoting factor Enzyme inhibitor

Translation terminating facto

The G protein involved in visual signal transduction is Rhodopsin GTP receptor Arrestin Transducin

Arrestin

Cholera toxin is not a/an Enzyme inhibitor Enzyme activator Enzyme modifier Toxin released from bacteria in the infected intestine

Enzyme activator

In cholera there is uncontrolled secretion of Na+ and H2O K+ and H2O Ca2+ and H2O Mg2+ and H2O

Na+ and H2O

Vision, olfaction and gustation employ Serpentine receptors Enzyme coupled receptors Ligand gated receptors Adhesion receptors

Serpentine receptors

Which out of the following statements about sense of smell is not true? Olfactory receptor cells are bipolar neurons, not replaced when damaged The chemicals are received by specific plasma membrane receptors in olfactory receptor cells Olfactory receptors do not adapt quickly The main areas of brain that interpret sense of smell be in the temporal and frontal lobes

Olfactory receptors do not adapt quickly

Most olfactory receptors are located on the Superior surface of nasal cavity Interior surface of nasal cavity Lateral surface of nasal cavity Medial surface of nasal cavity

Superior surface of nasal cavity

Objects are perceived by photo receptors because rods or cones Depolarize Hyperpolarize Repolarize Polarize

Hyperpolarize

Which of the following statements is not true about olfactory neurons? Axons of olfactory neurons combine to form olfactory nerves They synapse with cells in olfactory bulb They have receptors that react with odorants dissolved in fluid They are uni-polar neurons

They are uni-polar neurons

What is the relationship between olfactory sensors and gustatory sensors? Gustatory hair can also detect odorants Olfactory hair can also detect tastants Olfactory sensors provides information about substance that we are about to taste No relation

Olfactory sensors provides information about substance that we are about to taste

When visual stimulus reaches receptors in retina of eye, first process involving absorption of physical energy by receptors is Reception Transduction Coding Adaptation

Reception

When visual stimulus reaches receptors in retina of eye, second process involving absorption of physical energy by receptors is Reception Transduction Coding Adaptation

Transduction

How do steroid hormones produce their effects in cells? By activating key enzymes in metabolic pathway By binding to intracellular receptors and promoting transcription of specific genes By promoting degradation of specific m-RNAs By activating translation of certain m-RNAs

By binding to intracellular receptors and promoting transcription of specific genes

An example of positive regulator CAP Lac 1 gene Trp operon Met operon

CAP

An example of negative regulator CAP Lac 1 gene Nuclear receptors Phosphorylated STAT proteins

Lac 1 gene

Steroid regulatory proteins mediate the act by binding at Zinc finger motif Leucine zipper motif Helix turn helix motif Histone helix motif

Zinc finger motif

Which out of the following statements is true about gene regulation in bacteria? Repressor protein blocks transcription by binding to operator sequence Activator proteins bind near promoters and increase the efficiency of transcription Enhancers commonly regulate transcription Genes with related functions are often grouped together and have a single start codon

Repressor protein blocks transcription by binding to operator sequence

Steroid hormones receptor binds to ``` Hormone response elements in m-RNA Hormone response elements in DNA Hormone response elements in proteins Ribosomes to stimulate translation Cell membrane thereby increases permeability ```

Hormone response elements in DNA

Mode of action of steroid hormones involve Stimulation of DNA replication Stimulation of m-RNA transcription Inhibition of protein synthesis Secondary messenger

Stimulation of m-RNA transcription

The drug antagonist of estrogen is Tanoxifen Metformin Glucophage Victoza

Tanoxifen

The drug used to terminate early pregnancies is RU486 Metformin Glucophage Victoza

RU486

Plasma membrane protein predicted to have seen 7 transmembrane helices segment binds Progesterone Thyroid stimulating hormone Insulin Follicle stimulating hormone

Progesterone

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BIO CHEM 5 Flashcards

(102 cards)