BIOC192 Lecture 21 - Biotechnology in use Flashcards Preview

BIOC192 Lectures 3-38 > BIOC192 Lecture 21 - Biotechnology in use > Flashcards

Flashcards in BIOC192 Lecture 21 - Biotechnology in use Deck (7)
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1
Q

what 4 things can be made from recombinant DNA technology?

A

1) therapeutic products
2) genetically modified products
3) diagnosis (e.g gene therapy)
4) energy applications

2
Q

what is the post-translational modification for insulin and what is this best produced in?

A
  • post-translational modification= disulphide bonds

- best produced in= A and B chains separately in bacteria

3
Q

what is the post-translational modification for erythropoietin (EPO) and what is this best produced in?

A
  • post-translational modification= glycosylation

- best produced in= mammalian cell culture

4
Q

what is the post-translational modification for antithrombin (AT) and what is this best produced in?

A
  • post-translational modification= gamma carboxylation

- best produced in= transgenic animals (costs more but is the most effective method)

5
Q

what are recombinant DNA technologies in the clinic?

A

recombinant proteins that require repeated administration of drugs for the life of the patient/illness

6
Q

how can you provide a permanent treatment using biotechnology?

A

use patients as the host for protein production

7
Q

what is gene therapy?

A

introducing plasmids that can be carried into patients using viral vectors