Biochem Flashcards Preview

STEP1 > Biochem > Flashcards

Flashcards in Biochem Deck (10):
1

Which cells produce collagen?

fibroblasts

2

How much DNA would cells in G0 or G1 phase have?

They would have a diploid amount of DNA (2N)

3

How much DNA would cells in S-phase have?

Intermediate amounts of DNA between 2N and 4N

4

How much DNA would cells in G2 phase have?

They would have a tetraploid amount of DNA (4N)

5

What would be the ploidy of tumor cells?

half 2N, half 4N

6

What are the clinical manifestations of vitamin C deficiency?

vitamin C deficiency may present with bruising. This deficiency leads to easy bruising because of increased fragility of small blood vessels due to poor collagen formation around the small blood vessels.

7

What are Advance Glycosylation End (AGE) products?

these are insoluble proteins (mostly collagen and other long-lived proteins) that progressively accumulate in blood vessel walls due to glycosylation. This is a mechanism underlying damage in diabetes mellitus and aging.

8

On what chromosome is the gene for Huntington disease on?

Chromosome 4

("Hunting 4 food")

9

What type of genetic disorder is Huntington disease?

A trinucleotide repeat disorder (CAG)n.

An increase in the number of repeats --> decrease in the age of onset. This is known as anticipation (earlier onset of disease in subsequent generations)

10

Administration of what vitamin can prevent neural tube defects?

Folate