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Flashcards in Biochem Deck (10)
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1
Q

Which cells produce collagen?

A

fibroblasts

2
Q

How much DNA would cells in G0 or G1 phase have?

A

They would have a diploid amount of DNA (2N)

3
Q

How much DNA would cells in S-phase have?

A

Intermediate amounts of DNA between 2N and 4N

4
Q

How much DNA would cells in G2 phase have?

A

They would have a tetraploid amount of DNA (4N)

5
Q

What would be the ploidy of tumor cells?

A

half 2N, half 4N

6
Q

What are the clinical manifestations of vitamin C deficiency?

A

vitamin C deficiency may present with bruising. This deficiency leads to easy bruising because of increased fragility of small blood vessels due to poor collagen formation around the small blood vessels.

7
Q

What are Advance Glycosylation End (AGE) products?

A

these are insoluble proteins (mostly collagen and other long-lived proteins) that progressively accumulate in blood vessel walls due to glycosylation. This is a mechanism underlying damage in diabetes mellitus and aging.

8
Q

On what chromosome is the gene for Huntington disease on?

A

Chromosome 4

“Hunting 4 food”

9
Q

What type of genetic disorder is Huntington disease?

A

A trinucleotide repeat disorder (CAG)n.

An increase in the number of repeats –> decrease in the age of onset. This is known as anticipation (earlier onset of disease in subsequent generations)

10
Q

Administration of what vitamin can prevent neural tube defects?

A

Folate