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Flashcards in Heme/Onc4 Deck (1)
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1
Q

A newborn develops multiple hemorrhages. Lab studies show an elevated prothrombin time (PT). What process is most likely abnormal in this newborn?

A

This baby likely has a vitamin K deficiency, and has developed hemorrhagic disease of the newborn.

Glutamate residues on factors 2, 7, 9, and 10must be gamma-carboxylated (in a reaction that requires vitamin K) in order for these factors to be activated.