What does the Henderson-Hasselbalch Equation Explain?
The ratio of protonated to unprotonated form present at a particular pH when compared to the pKa of the compartment.
Name an attribute that may change when the pH a drug is exposed goes above or below that drug's pKa? This attribute is important to drug absorption, where it becomes distributed in the body, and its excretion.
Whether the drug is predominantly charged or uncharged.
Draw the curve for pH vs net charge for the antibiotic ciprofloxacin. Ciprofloxacin has a carboxylic acid group with a pKa of approximately 6, and a second basic piperazinyl group at approximately 8.8. The net charge ranges from +1 to uncharged to -1. Will ciprofloxacin be mostly charged or neutral while dissolving in the small intestine, which has a pH of 7.5 to 8.0?