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Flashcards in Biochemistry Deck (37):
1

what is the ion responsible for phase 0 (upstroke) of SAN AP?

Calcium

2

what is ion responsible for phase 4 (gradual incline/If) of SAN AP?

Na

3

in calcium-indiced-calcium release, what is role of cAMP?

phosphorylates ryanodine receptor allowing calcium to exit SR into cell and phosphorylates SERCA-PLB receptor to allow Ca to return into SR

4

does angiotensin II induce myocardial contraction?

no

5

what are adrenergic receptors all coupled to?

G-proteins

6

what does alpha 1 receptor do?

vasoconstriction

7

alpha 2 receptor

vasodilation (inhibition of axonal NE release)

8

Beta 1 receptor

myocardial contraction and chronotropy

9

Beta 2 receptor

vasorelaxation

10

what receptor does clonidine bind to?

alpha 2 (presynaptic NE)

11

which receptors does epinephrine hit?

a1, B1 ,B2

12

which receptors does Norepi hit?

a1, B1

13

which receptors does dobutamine hit?

B1, B2

14

which receptors does phenylephrine hit?

a1

15

which receptors does phentolamine hit?

a2

16

which receptors does propranolol hit?

B1, B2

17

name 3 receptors that are in vasculature.

alpha 1, 2, B2

18

name 1 receptor in myocardium (biochem lecture)

B1

19

what is ligand for parasympathetic receptors?

acetylcholine

20

what does acetylcholine do to a vessel if there is intact endothelium? what about denuded endothelium?

increase NO--> vasodilation
can't inc NO--> vascononstriction

21

which of the following is a direct thrombin inhibitor: rivaroxaban, dabigatran?

dabigatran

22

when there is tissue injury, is it the intrinsic or extrinsic clotting pathway that first gets activated?

extrinsic

23

name the enzyme inhibited by fondaparniux, rivaroxaban, apixaban

Xa

24

what is inheritance pattern of Becker's CM?

X-linked

25

what is inheritance pattern of Marfan's?

Autosomal Dominant

26

which gene and what chrome. is responsible for Marfan's?

fibrillin , chrom 15

27

is Ao usually involved in Ehler's Danlos?

no

28

what chess wall deformity is associated with marfans?

pectus excavatum

29

what is main inheritance pattern for long QT syndrome?

AD

30

what is main inheritance pattern for Brugada syndrome?

AD

31

is brugada syndrome a gain or loss of fxn and what gene is involved?

loss of fxn
SCN5A

32

inheritance pattern of familial hypercholesterolemia?

AD

33

which disease has an autosomal dominant inheritance pattern with variable penetrance and sarcomeric mutation?

HCM

34

what is the most frequent mutation in HCM?

myosin binding Protein C

35

what is the myocardium's preferred source of energy?

FA's

36

do BB's prevent poor calcium flux intracellularly?

yes

37

in CHF, is there emote calcium in the cytosol or SR?

cytosol