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Flashcards in Cardiomyopathies Deck (45):
0

3 chemo therapies that can cause DCM

Daunoribicin
Doxorubicin
Sunitinib
Trastuzumab
Cyclophosphamide
Bleomycin

1

Organic solvent that causes DCM

Toluene

2

Party drugs that can cause DCM

ETOH
Cocaine

3

Heavy metals that can cause DCM

Mercury
Lead
Cobalt

4

Antiretrovirals that can cause DCM (3)

Zidovudine
Didanosine
Zalcitabine

5

Time frame for peripartum CM

Last month of pregnancy to 5 mo's after

6

Risk factors for peripartum CM

Age> 30
Multiparity
AA
h/o preeclampsia or postpartum HTN
cocaine

7

Drug of choice in pregnant women instead of ACEI

hydralazine

8

Population at risk of Takotsubo
Percent risk of ventricular arrhythmias?

Postmenopausal women
15%

9

Recurrence rate for Takotsubo

4%

10

Bugs causing HIV focal myocarditis

HIV
CMV
EBV
coxsackie
Toxoplasma

11

Inheritance pattern of muscular dystrophies.
Which is worse (Becker's or Duchenne's) for CM?

X-linked
Becker's

12

When should you suspect anthracycline induced CM (daunorubicin)?
Risk factors

Dose dependent> 550mg/m2
3-12 months after.
Can occur upto 10y later
DM, HTN,

13

If high doses of daunorubicin needed,what med to give to avoid CM?

Dexrazoxane, ACEI, BB

14

Difference in LVEDD b/w HCM and athlete

HCM: LVEDD <45

15

What type of activity is OK with HCM?

Low level

16

3 factors making SAM worse in HOCM

Increased contraction
Decreased resistance (vasodilator)
Decreased volume

17

Preferred Rx in HOCM (myomectony vs. septal ablation)

Myomectony

18

LV wall thickness in HOCM

> 1.5cm

19

7 risk factors are needed to place ICD in HOCM. Not including VT/VF/SCA, what are the 5 other risk factors?

Fam hx of SCD
LV thickness > 3cm
Recent unexplained syncope
NSVT
BP drop w/ exercise

20

Do steroids help for myocarditis

NO!

21

Treatment for myocarditis with reduced LV function

ACEI
BB

22

Will you see myofiber necrosis on biopsy of myocarditis?

Yes

23

8 common viral Pathogens causing myocarditis

CMV
Coxsackie B
Hep C
Echo
Adeno
Parvovirus
Influenza

24

Which biomarkers are more sensitive in myocarditis?

Trops

25

What do you see on MRI of myocarditis

Late gad

26

Do you do routine bx for myocarditis?

No

27

Rx and followuo of myocarditis

HF meds
Echo at 1, 6, and 12

28

Giant cell myocarditis is progressive and often fatal, Rx?

Thymoglobulin
Corticosteroids
Calcineurin inhibitors

29

Giant cell myocarditis- which immune cell?
Is biopsy high yield?

T cell
Yes

30

Acute phase treatment of chagas HF?

Nitrofurtimox

31

3 cardiac issues Lyme will cause

DCM
HB (arrhythmias)
Myocarditis

32

Lyme carditis bug and treatment and serologies

IgM
Ceftriaxone
Bordelaise burgdorferi

33

2 things to remember about lupus CM

Can wax and wane- treat the lupus flare
Systolic and diastolic dysfxn

34

What does cardiac bx show in lupus?

Mononuclear cells

35

Fever, rash, peripheral eos and eos on cardiac bx.
Dx and Rx?

Hypersensitivity Myocarditis
Remove any offending meds and give steroids

36

Hoarseness, macroglossia, neuropathy, proteinuria, swallowing disorder, RUQ tenderness. Exam: JVD w/ prom x and y descent, pleural effusions, hepatomegaly, edema, KUSSMAUL's and S3 & S4. Dx, echo, EKG, Bx findings.

Cardiac amyloid
Speckled appearance, LVH
low voltage
Apple green birefringence

37

Management of transthyretin gene mutant cardiac amyloid

Family genetic testing
Live transplant

38

Which amyloid has better prognosis (senile or AL)?

Senile

39

2 studies that are high yield to diagnose amyloid

MRI (late gad)
Bx

40

Nuclear and echo findings with cardiac sarcoid

Regional WMA
perfusion defect

41

Do you get late gad enhancement on MRI with cardiac sarcoid?

Yes

42

Exact treatment for cardiac sarcoid

Corticosteroids 1mg/kg we'd x 3 months
Low threshold for ICD

43

Common secondary cause for cardiac hemochromatosis

Multiple transfusions

44

How to diagnose cardiac hemochromatosis? Rx?

T2* MRI
chelation/phlebotomy