BIOL1025 - Hydrophilic signalling - Enzyme linked(coupled) receptor

Question 1

enzyme linked receptor

Answer 1

transmembrane protein with ligand binding domain on extracellular end and enzymatic domain inside cell

Question 2

activation of receptor

Answer 2

binding of ligand found in 2 forms

Question 3

2 forms of ligand

Answer 3

receptor tyrosine kinase - e.g. insulin and FGF receptors

receptor serine/threonine kinase - e.g. bone morphogenetic protein(BMG) and TGFb

Question 4

FGF

Answer 4

fibroblast growth factor

Question 5

RTKs

Answer 5

receptor tyrosine kinase

Question 6

process (1)

Answer 6

domain has tyr/ser/thr kinase sat within cell

Question 7

inactive form (2)

Answer 7

proteins are separated

Question 8

signalling molecule (3)

Answer 8

act as dimer
bind to binding site of RTKs
causing 2 proteins to come in close proximity - phosphorylates each other

Question 9

after phosphorylation (4)

Answer 9

open up sited ion internal parts caused by conformational changes
other proteins bind

Question 10

some cases of binding - grouping

Answer 10

kinase groups up at phosphate groups and goes off

Question 11

other cases of binding - complex

Answer 11

receptor acts as surface for other proteins to attach forming large signalling complexes for signalling events to take place

Question 12

activating intracellular signalling proteins

Answer 12

activation of down stream intracellular signalling pathways