Biologics

Question 1

Biologics are similar to small molecule chemo drugs.

a. true
b. false

Answer 1

b. false

biologics are totally different from small molecule chemo drugs

Question 2

What is a key mechanism of biologics for cancer therapy?

Answer 2

to induce the body’s immune system to recognize and attack cancer cells

Question 3

What is the brand name of recombinant IL2?

Answer 3

Proleukin

Question 4

How does IL2 work against cancer?

Answer 4

endogenous and exogenous activate T cells and NK cells

Question 5

What is brand name of recombinant human IFN alpha 2 b?

Answer 5

Heberon alfa R

Question 6

What is brand name of IFN alpha 2b?

Answer 6

Intron-A

Question 7

What is used to treat viral infections and cancers such as chronic hep C/B, hairy cell leukemia, etc?

Answer 7

interferon alfa 2b

Question 8

2 antibody drug conjugates:

Answer 8

gemtuzumab

ibritumomab

Question 9

Suffix for human mabs?

Answer 9

-mumab

Question 10

Suffix for chimeric mabs?

Answer 10

-ximab

Question 11

suffix for mouse mabs?

Answer 11

-momab

Question 12

suffix for humanized mabs?

Answer 12

-zumab

Question 13

List the types of antibody according to their potency in induction of immunological reactions inside human body, from the strongest to the weakest:

Answer 13

mouse (momab), chimeric (ximab), humanized (zumab), human (mum)

Question 14

Antibodies can be __ with a variety of substances to enhance anticancer effects, including chemo-drugs, protein toxins, radionuclides, prodrug-activating enzymes, etc.

Answer 14

conjugated

Question 15

ado-trastuzumab emtanvine target?

Answer 15

HER2

Question 16

bevacizumab target?

Answer 16

VEGF ligand

Question 17

cetuximab target?

Answer 17

EGFR

Question 18

daratumumab target?

Answer 18

PD-1

CD38

Question 19

elotuzumab target?

Answer 19

SLAMF7

Question 20

gemtuzumab target?

Answer 20

CD33

Question 21

ipilimumab target?

Answer 21

CTLA-4

Question 22

obinutuzumab target?

Answer 22

CD20

Question 23

panitumumab target?

Answer 23

EGFR

Question 24

pembrolizumab target?

Answer 24

PD-1

Question 25

pertuzumab target?

Answer 25

HER2

Question 26

rituxumab target?

Answer 26

CD20

Question 27

trastuzumab target?

Answer 27

HER2

Question 28

bevacizumab brand name?

Answer 28

Avastin

Question 29

bevacizumab (Avastin) blocks what?

Answer 29

angiogenesis inhibits VEGF-A

Question 30

pembrolizumab brand name?

Answer 30

Keytruda

Question 31

Which mab targets the programmed cell death protein (PD-1) of lymphocytes?

Answer 31

pembrolizumab (Keytruda)

Question 32

Which mab is FDA approved for any unresectable/metastatic solid tumor with certain genetic anomalies?

Answer 32

pembrolizumab (Keytruda)

Question 33

bevacizumab (Avastin) is approved for use with __ therapy for second line metastatic colorectal cancer

Answer 33

5-FU

Question 34

Which mab is approved for non squamous non small cell lung cancer in combo with carboplatin/paclitaxel?

Answer 34

bevacizumab (Avastin)

Question 35

Which mab is approved for treatment of metastatic renal cell cancer and recurrent glioblastoma multiform?

Answer 35

bevacizumab (Avastin)

Question 36

What mab is an antibody drug conjugate of cytotoxic DM1?

Answer 36

ado-trastuzumab emtanvine (T-DM1)

Question 37

What is rand name of ado-trastuzumab?

Answer 37

Kadcyla

Question 38

What is brand name of ibritumomab?

Answer 38

Zevalin

Question 39

What mab is radioimmunotherapy Tx formed by mouse IgG1 conjugated with tiuxetan?

Answer 39

ibritumomab

Question 40

Which mab is conjugated to Yttrium-90?

Answer 40

ibritumomab

Question 41

Why do antibody targets (epitopes) need to be on the cell surface?

Answer 41

antibody based drugs cannot penetrate the cell membrane

Question 42

Targeting PD-1 (pembrolizumab) causes what?

Answer 42

elevated production of autocrine paracrine cytokines, causing greater cytotoxicity

Question 43

Two therapies that are only highly effective in a small subpopulation of cancer pts with biomarkers?

Answer 43

CTLA-4 | PD-1

Question 44

Therapeutic cancer vaccine (tCV) prevents cancer occurrence. a. true b. false

Answer 44

b. false

Question 45

What is the brand name of the first cell based therapeutic cancer vaccine?

Answer 45

Provenge sipuleucel-T personalized medicine

Question 46

What is brand name of first CAR-T cell therapy?

Answer 46

Kymriah tisagenlecleucel personalized medicine

Question 47

What is T-VEC?

Answer 47

first oncolypic viral therapy

Question 48

What is the brand name of oncolypic viral therapy, T-VEC?

Answer 48

Imlygic

Question 49

How is T-VEC (Imlygic) administered?

Answer 49

directly injected into melanoma tumors