Targeted Therapies Flashcards
(116 cards)
1
Q
bortezomib (Velcade) primary target?
A
26S proteasome
2
Q
ixazomib (Nilaro) primary target?
A
26S proteasome
3
Q
venetoclax (Venclexta) primary target?
A
BCI-2
4
Q
ponatinib (Iclusig) primary target?
A
BCR-ABL
5
Q
nilotinib (Tasigna) primary target?
A
BCR-ABL
6
Q
imatinib (Gleevec) primary target?
A
BCR-ABL
7
Q
dasatinib (Sprycel) primary target?
A
BCR-ABL
8
Q
bosutinib (Bosulif) primary target?
A
BCR-ABL
9
Q
vemurafenib (Zelboraf) primary target?
A
BRAF
10
Q
dabrafenib (Tafinlar) primary target?
A
BRAF
11
Q
ibrutinib (Imbruvica) primary target?
A
BTK (Bruton’s tyrosine kinase)
12
Q
palbociclib (Ibrance) primary target?
A
CDK4/CDK6 (cyclin dependent kinase)
13
Q
ribociclib (Kisqali) primary target?
A
CDK4/CDK6 (cyclin dependent kinase)
14
Q
abemaciclib (Verzenio) primary target?
A
CDK4/CDK6 (cyclin dependent kinase)
15
Q
erlotinib (Tarceva) primary target?
A
EGFR
16
Q
osimertinib (Tagrisso) primary target?
A
EGFR
17
Q
crizotinib (Xalkori) primary target?
A
EML4-ALK
18
Q
alectinib (Alecensa) primary target?
A
EML4-ALK
19
Q
midostaurin (Rydapt) primary target?
A
FLT3
20
Q
panobinostat (Farydak) primary target?
A
HDAC
21
Q
lapatinib (Tykerb) primary target?
A
HER2
22
Q
trametinib (Mekinist) primary target?
A
MEK
23
Q
cobimetinib (Cotellic) primary target?
A
MEK
24
Q
temsirolimus (Torisel) primary target?
A
mTOR
25
everolimus (Afinitor) primary target?
mTOR
26
thalidomide (Thalomid) primary target?
multiple targets
27
pamalidomide (Pomalyst) primary target?
multiple targets
28
lenalidomide (Revlimid) primary target?
multiple targets
29
olaparib (Lynparza) primary target?
PARP
30
niraparib (Zejula) primary target?
PARP
31
idelalisib (Zydelig) primary target?
PI3K-delta
32
sunitinib (Sutent) primary target?
VEGFR2
33
regorafenib (Stivarga) primary target?
VEGFR2
34
pazopanib (Votrient) primary target?
VEGFR2
35
sorafenib (Nexavar) primary target?
VEGFR2
36
axitinib (Inlyta) primary target?
VEGFR2
37
cabozanitinib (Cabometyx) primary target?
VEGFR2
38
venetoclax target class?
anti-apoptotic protein inhibitor
39
Drugs that target BCR-ABL fall into what class?
kinase inhibitors
40
Drugs that target BRAF fall into what class?
kinase inhibitors
41
Drugs that target BTK fall into what class?
kinase inhibitor
ibrutinib
42
Drugs that target CDK4/CDK6 fall into what class?
kinase inhibitor
43
Drugs that target EGFR fall into what class?
kinase inhibitors
44
Drugs that target EML-4-ALK fall into what class?
kinase inhibitors
45
Drugs that target FLT3 fall into what class?
kinase inhibitor
46
Drugs that target HDAC fall into what class?
enzyme inhibitor
panobinostat
47
Drugs that target HER2 fall into what class?
kinase inhibitors
48
Drugs that target MEK fall into what class?
kinase inhibitor
trametinib, cobimetinib
49
Drugs that target mTOR fall into what class?
kinase inhibitors
temsirolimus, everolimus
50
Thalidomide, pamilidomsde, and lenalidomide fall into what class?
immunomodulatory amide drugs (IMiDs)
51
Drugs that target PARP fall into what class?
enzyme inhibitor
olaparib, niraparib
52
Drugs that target PI3K-delta fall into what class?
kinase inhibitor
idelalisib
53
Drugs that target VEGFR2 fall into what class?
kinase inhibitors
sunitinib, regorafenib, pazopanib, sorafenib, axitinib, cabozantinib
54
bortezomib is used to treat what two diseases?
multiple myeloma
| mantle cell lymphoma
55
ixazomib is used to treat what disease?
multiple myeloma
56
venetoclax is used to treat what two diseases?
certain leukemias
| certain lymphomas
57
ponatinib is used to treat what two diseases?
Ph+ CML
| Ph+ AML
58
nilotinib is used to treat what disease?
Ph+ CML
59
imatinib is used to treat what 3 diseases?
Ph+ CML
Ph+ AML
GIST (due to c-KIT activity)
60
dasatinib is used to treat what two diseases?
Ph+ CML
| Ph+ AML
61
bosutinib is used to treat what disease?
Ph+ CML
62
vemurafenib is used to treat what disease?
V600E melanoma
63
dabrafenib is used to treat what disease?
V600E melanoma
64
ibrutinib is used to treat what disease?
B-cell lymphomas and leukemias
65
palbociclib is used to treat what disease?
HR+, HER2 negative breast cancer
66
ribociclib is used to treat what disease?
HR+, HER2 negative breast cancer
67
abemaciclib is used to treat what disease?
HR+, HER2 negative breast cancer
68
erlotinib is used to treat what disease?
NSCLC with EGFR activating mutations
69
osimertinib is used to treat what disease?
NSCLC with EGFR activating mutations
70
crizotinib is used to treat what disease?
NSCLC with EML4-ALK
71
alectinib is used to treat what disease?
NSCLC with EML4-ALK
72
midostaurin is used to treat what disease?
AML with FLT3 activating mutations
73
panobinostat is used to treat what disease?
multiple myeloma
74
lapatinib is used to treat what disease?
HER2+ breast cancer
75
trametinib is used to treat what disease?
V600E melanoma
76
cobimetinib is used to treat what disease?
V600E melanoma
77
temsirolimus is used for?
post transplant immunosuppressive therapy and certain cancers
78
everolimus is used for?
post transplant immunosuppressive therapy and certain cancers
79
thalidomide is used to treat?
multiple myeloma
80
pamalidomide is used to treat?
multiple myeloma
81
lenalidomide is used to treat?
multiple myeloma
82
olaparib is used to treat?
BRCA mutated breast or ovarian cancer
83
niraparib is used to treat?
BRCA mutated breast or ovarian cancer
84
idelalisib is used to treat?
CLL and NHL
85
sunitinib is used to treat what 3 diseases?
RCC
pancreatic cancer
GIST (due to c-KIT activity)
86
regorafenib is used to treat?
metastatic colon cancer
87
pazopanib is used to treat what 2 things?
RCC
| soft tissue sarcomas
88
sorafenib is used to treat 3 things?
RCC
thyroid cancer
hepatocellular carcinoma
89
axitinib is used to treat?
RCC
90
cabozantinib is used to treat?
RCC
91
__ has a BBW for arterial thrombosis and hepatotoxicity
ponatinib
92
__ has a BBW for QT prolongation
nilotinib
93
__ has a BBW for severe diarrhea and potentially fatal cardiac events
panobinostat
94
lapatinib has a BBW for __
hepatotoxicity
95
thalidomide has a BBW for __
severe birth defects, thromboembolism
96
pamalidomide has a BBW for __
severe birth defects, thromboembolism
97
lenalidomide has a BBW for __
severe birth defects
thromboembolism
myelosuppression
98
___ has a BBW for hepatotoxicity, pneumonitis, and GI distress
idelalisib
99
sunitinib has a BBW for ___
hepatotoxicity
100
regorafenib has a BBW for ___
hepatotoxicity
101
pazopanib has a BBW for __
hepatotoxicity
102
Which two agents can cause acneiform rash?
erlotinib
| lapatinib
103
__ should be taken with a low fat meal
regorafenib
increases exposure
104
ixazomib should be taken with or without food?
without
take on empty stomach
105
venetoclax should be taken with or without food?
with food
increases exposure
106
nilotinib should be taken with or without food?
without food
take on empty stomach
107
bosutinib should be taken with or without food?
with food
108
erlotinib should be taken with or without food?
without food
take on em[pty stomach
109
midostaurin should be taken with or without food?
take twice daily with food
110
lapatinib should be taken with or without food?
without food
take on empty stomach
111
trametinib should be taken with or without food?
without food
take on empty stomach
112
sorafenib should be taken with or without food?
without food
take on empty stomach
113
__ is effective against T315I mutant
ponatinib
114
__ is an irreversible inhibitor
ibrutinib
115
__ contains a boronic functional group and is dosed IV
bortezomib
| osimertinib
116
___ is effective versus T790M gatekeeper mutan
osimertinib
irreversible inhibitor
