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7361 Hem/Onc Block 1 > Chemotherapeutic Drugs > Flashcards

Chemotherapeutic Drugs Flashcards

(74 cards)

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1
Q

chlorambucil drug class?

A

nitrogen mustard DNA alkylating agent

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2
Q

bendamustine drug class?

A

nitrogen mustard DNA alkylating agent

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3
Q

melphalan drug class?

A

nitrogen mustard DNA alkylating agent

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4
Q

cyclophosphamide drug class?

A

nitrogen mustard DNA alkylating agent

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5
Q

ifosfamide drug class?

A

nitrogen mustard DNA alkylating agent

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6
Q

busulfan drug class?

A

(bis)methylsulfonate ester DNA alkylating agent

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7
Q

carmustine drug class?

A

nitrosurea DNA alkylating agent

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8
Q

lomustine drug class?

A

nitrosurea DNA alkylating agent

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9
Q

dacarbazine drug class?

A

DNA methylating agent

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10
Q

temozolomide drug class?

A

DNA methylating agent

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11
Q

procarbazine drug class?

A

DNA methylating agent

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12
Q

cisplatin drug class?

A

platinum agent

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13
Q

carboplatin drug class?

A

platinum agent

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14
Q

oxaliplating drug class?

A

platinum agent

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15
Q

bleomycin drug class?

A

DNA intercalation agent

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16
Q

ironotecan drug class?

A

camptothecin topoisomerase inhibitor

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17
Q

topotecan drug class?

A

camptothecin topoisomerase inhibitor

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18
Q

etoposide drug class?

A

epipodophyllotoxin topoisomerase inhibitor

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19
Q

teniposide drug class?

A

epipodophyllotoxin topoisomerase inhibitor

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20
Q

doxorubicin drug class?

A

anthracycline topoisomerase inhibitor

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21
Q

epirubicin drug class?

A

anthracycline topoisomerase inhibitor

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22
Q

valrubicin drug class?

A

anthracycline topoisomerase inhibitor

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23
Q

daunorubucin drug class?

A

anthracycline topoisomerase inhibitor

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24
Q

idarubicin drug class?

A

anthracycline topoisomerase inhibitor

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25
mitoxantrone drug class?
anthracenedione topoisomerase inhibitor do not confuse with anthraCYCLINE topo inhibitors
26
arsenic trioxide drug class?
heavy metal
27
hydroxyurea drug class?
cytotoxic enzyme inhibitor
28
5-fluorouracil drug class?
pyrimidine antimetabolite
29
capecitabine drug class?
pyrimidine antimetabolite
30
cytarabine drug class?
cytidine antimetabolite
31
gemcitabine drug class?
cytidine antimetabolite
32
azacytidine drug class?
cytidine antimetabolite
33
decitabine drug class?
cytidine antimetabolite
34
mercaptopurine drug class?
purine antimetabolite
35
fludarabine drug class?
purine antimetabolite
36
cladribine drug class?
purine antimetabolite
37
methotrexate drug class?
antifolate
38
pemetrexed drug class?
antifolate
39
pralatrexate drug class?
antifolate
40
leucovorin drug class?
folate
41
levoleucovorin drug class?
folate
42
allopurinol drug class?
xanthine oxidase inhibitor
43
paclitaxel drug class?
taxane antimitotic
44
docetaxel drug class?
taxane anti mitotic
45
cabazitaxel drug class?
taxane antimitotic
46
vincristine drug class?
vinca alkaloid antimitotic
47
vinblastine drug class?
vinca alkaloid antimitotic
48
vinorelbine drug class?
vinca alkaloid anti mitotic
49
ixabepilone drug class?
epothilone anti mitotic
50
MOA of nitrogen mustard DNA alkylating agents?
alkylation of N7 of guanine nucleases leading to formation of INTERstrand cross-links chlorambucil, bendamustine, melphalan, cyclophosphamide, ifosfamide
51
MOA of busulfan?
alkylation of N7 guanine nucleases leading to formation of INTERstrand cross links same as nitrogen mustards
52
MOA of nitrosurea DNA alkylating agents carmustine and lomustine?
Lkylation of O6 guanine nucleobases leading to INTERstrand cross links
53
MOA of DNA methylating agents dacarbazine, temozolomide, procarbazine?
methylation of O6 guanine nucleobases
54
MOA of platinum agents cisplatin, carboplatin, oxaliplatin?
alkylation of DNA leading to INTRAstrand cross links
55
MOA of DNA intercalation agent bleomycin?
causes DNA free radicals that lead to strand breaks
56
MOA of ironotecan and topotecan?
bind and stabilize DNA TOPOISOMERASE I, blocking the resealing of SINGLE strand breaks
57
MOA of etoposide, etoposide phosphate, teniposide?
bind and stabilize DNA TOPOISOMERASE II, blocking resealing of DOUBLE strand breaks epidopophyllotoxin topoisomerase inhibitors
58
MOA of doxorubicin, epirubicin, valrubicin, daunorubicin, idarubicin?
bind and stabilize DNA TOPOISOMERASE II, blocking resealing of DOUBLE strand breaks anthracycline topoisomerase inhibitors
59
MOA of mitoxantrone?
bind and stabilize the DNA TOPOISOMERASE II complex, blocking resealing of DOUBLE strand breaks anthraCENDEDIONE topoisomerase inhibitor same MOA as anthracyclines
60
MOA of the heavy metal arsenic trioxide?
destruction of fusion protein from reciprocal translocation of chromosomes 15 and 17
61
MOA of hydroxyurea?
ribonucleotide reductase inhibitor cytotoxic enzyme inhibitor
62
MOA of 5-fluorouracil?
thymidylate synthase inhibitor pyrimidine antimetabolite
63
capecitabine MOA?
thymidylate synthase inhibitor (oral prodrug for 5-FU)
64
Which drug is an oral prodrug for 5-FU?
capecitabine
65
MOA of cytidine antimetabolites cytarabine, gemcitabine?
DNA polymerase inhibitors
66
MOA of azacytidine and decitabine?
DNA methyltransferase inhibitors cytarabine and gemcitabine are polymerase inhibitors
67
MOA of purine antimetabolites mercaptopurine?
Tase inhibitor, which blocks biosynthesis of AMP and GMP
68
MOA of purine antimetabolites fludarabine and cladribine?
DNA polymerase inhibitor
69
MOA of methotrexate, pemetrexed, and pralatrexate?
dihydrofolate reductase (DHFR) inhibitors antifolates
70
MOA of folate leucovorin and levoleucovorin?
enhance activity of 5-FU folates
71
allopurinol is used to increase __ exposure
mercaptopurine
72
MOA of taxane anti mitotics paclitaxel, docetaxel, cabazitaxel?
promote microtubule assembly and stabilize microtubules thus inhibiting disassembly taxane antimitotics
73
MOA of vinca alkaloid antimitotics vincristine, vinblastine, vinorelbine?
inhibition of microtubule assembly
74
MOA of epothilone anti mitotic ixabepilone?
promote microtubule assembly and stabilize microtubules, thus inhibiting their disassembly

7361 Hem/Onc Block 1 (9 decks)

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