Bipolar Pharmacology Flashcards
(22 cards)
what does lithium do to GABA neurotransmission
increases/augments it
3 things that deplete inositol
valproic acid
carbamazepine
lithium
true or false
lithium enhances calcium mediated vesicular transmitter release
FALSE - inhibits
true or false
lithium inhibits inositol triphosphate/diacyglycerol signaling
true
true or false
lithium inhibits glycogen synthase kinase 3 beta
true
side effects of lithium
nephro (kidney) toxic
tremors
thirst
increase urination
muscle weakness
lack of coordination
sleepy
carbamazepine is used for bipolar patients who have nor responded well to….
lithium therapy
true or false
for patients experiencing “mixed mania” or mania with depression features, VALPROATE is preferred over lithium
true
true or false
valproate can be used alone or in combo with carbamazepine and/or lithium
true
clozapine use in bipolar
controls manic episodes in pts who haven’t responded to typical mood stabilizers
OCD medications
SSRIS
effective with minimal AE!
2 neurotransmitters affected in bipolar
dopamine (too high) and GABA (too low)
issue with using SSRI/SNRI in bipolar
may worsen the manic phase
can lithium be used in combo with antipsychotics
yes
**lithium specific MOA
inhibits the IP3/DAG pathway
inhibits glycogen synthase kinase-3B
true or false
tremor caused by lithium may actually start in the therapeutic range
true
then gets more serious as you increase the dose
true or false
lithium has a neuroprotective effect
true
increases BDNF (brain derived neurotropic factor)
lithium substitutes for ___ in the brain which can lead to axonal degeneration
sodium
true or false
diabetes insipidus is not an AE of lithium
FALSE - it is
*****ONE OF MAIN DRUGS USED FOR MANIA
lithium
why are TCAs not really used for OCD
highest risk of antimuscarinic toxicity
