Blackboard Q's path Flashcards by Scott Godfrey

Prevents DNA replication especially of T cells

Mycophenolate mofetil

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Causes a transient increase in neutrophil count

Prednisolone

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Immunisation still effective in this immunodeficiency syndrome

IgA def

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Lymphocyte associated w/ HLA DR

CD4+

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Lymphocyte associated w/ HLA A

CD8+

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Most important cell in initiation of normal haemostasis

Endothelial

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Main componenet involved in stabilising the primary haemostatis plug

Fibrin

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Serine protease which assists in the break down of blood clots by binding to the clot and localising agents which break it down

Tissue-plasminogen activator (t-PA)

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Potent plasmin inhibitor in the blood

a2 macroglobulin

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MOA Heparin

Potentiates antithrombin

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Measuring heparin activity

APTT

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Measuring Warfarin activity

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Cyclic endoperoxides that induces plt aggregation

Thromboxane A2

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Vit K dependent not serine protease

Protein S

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Cofactor for protein C activity

Protein S

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What synthesises tissue factpr, vWF, Prostacyclin, plasminogen activator, antithrombin III and Thrombomodulin

Vascular endothelium

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Clotting factor that activates both FV and FVIII

Thrombin (FIIa)

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Normal PT, inc APTT, normal plt count, dec FVIII and dec vWF

5yo

vWD

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IV drug MOA: potentiates Antithrombin

Unfractionated heparin (UFH)

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SubCut drug MOA: potentiates Antithrombin

Dalteparin (LWMH)

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Reflects the amount of activity of fibrinogen

Thrombin Time

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> 20% blast cells in BM

AML

Dehdration and burning in fingers after hot bath (i.e. artificially raised Hb)

Pseudopolycythaemia

CLL w/ new endobronchial mass/lymphoma

Richter’s syndrome

Chemo pt, HTN, HyperK,

Tumour-lysis syndrome

Commonest adult leukaemia

CLL

3 phases of CML

Chronic (<5% blasts) Tx: Imatinib Accelerted (>10% blasts) Blast (>20% blasts)

Neutrophil infiltrat, stomach erosions

Acute gastritis

Gastroenteritis Staph A WCC effect

normal, too acute

Final metabolite of Acyclovir

Acyclovir triphosphate | Herpes S

Owl eye inclusion

CMV | Gancyclovir

Hairy leukoplakia

EBV, acyclovir

Vaccine thats contraindicated when hypersens to eggs

Influenza

2nd line when allergic to penicillin

Erythromycin

Canned food

Clostridium botulinum

Sub-unit/conjugate vaccine

Pneumococcal vaccine

Live attenuated

BCG, MMR, Yellow fever, Typhoid, Polio

Detoxified exotoxin vaccine

Tetanus

Recombinant DNA vaccine

HepB

Which organism does the BCG contain

Mycobacterium bovis

Conjugate vaccine

HiB

ETOH and B?

B1 Thiamine

Pellagra

B3. Dementia, Diarrhoea, dermatitis

Megaloblastic anaemia

Folate def

Pernicious anaemia

B12 def

Askanazy cell

Hashimotos

Prostate Ca

Acid phosphatase

Rapid cardiac enzyme rise after MI

Creatine kinase MB

Increased osteoblastic activity

ALP

6 hrs, 12 hrs and inc for 3+ days cardiac marker

Troponin

Def of which enzyme can cause SCID

Adenosine deaminase

Fabry's

Galactosidase A

3 drugs contraindicated in porphyria

Diclofenac, ETOH, co-trimoxazole