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Immuno EMQ notes Flashcards

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1
Q

Diminished T-cell count, non-funtional B-cells, IL-2 receptor mutation

A

SCID

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2
Q

Congenital neutropenia

A

Kostmann’s

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3
Q

Diminished B-cells, IgA/M/G, tyrosine kinase defect, BTK

A

Bruton’s

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4
Q

Crohn’s leading to loss of proteins and recurrent infx

A

Protein losing enteropathy

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5
Q

Mutation in CD40 ligand, Inc IgM, def IgA/E/G

A

Hyper IgM

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6
Q

High neutrophil count, Nitro Blue Tetrazolium (NBT) +ve

A

Leukocyte adhesion deficiency

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7
Q

Cyclical infx, elastase gene (ELA2)

A

Cyclical neutropenia

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8
Q

Nose bleeds, easy bruising, GI bleeds, reduced IgM, increased IgA+IgE

A

Wiskott-Aldrich syndrome

WASp gene mutation

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9
Q

MHC III mutation, low IgG, IgE, IgA

A

Common variable immunodeficiency Complement

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10
Q

Nitro-blue-tetrazolium test -ve, pneumonia, abscesses, X linked, NADPH oxidase defect

A

Chronic granulomatous disease

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11
Q

MHC I/II deficiency, sclerosing cholangitis, hepatomegaly, jaundice

A

Bare lymphocyte syndrome

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12
Q

recurrent chest and diarrhoeal illnesses

A

Selective IgA def

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13
Q

Granulocyte and lymphocyte deficiency

A

Reticular dysgenesis

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14
Q

Mouse monoclonal Ab targeted at CD3, used in allograft transplatation

A

OKT3/muromonab-CD3

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15
Q

Inhibits calcineurin, gum hyperplasia

A

Cyclosporine A

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16
Q

Anti-metabolite drug used in immunosupressive therapy, purine analogue

A

Azathioprine

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17
Q

Binds to FKBP-1a

A

Sirolimus

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18
Q

Binds to FKBP-1a targeting T-cell activation

A

Tacrolimus

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19
Q

Anti-CCP

A

RA

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20
Q

Anti-smooth muscle

A

Autoimmune hepatitis

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21
Q

Anti-jo, rash around eyes, pulmonary effects

A

Dermatomyositis

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22
Q

Reynaud’s, difficulty swallowing, anti-centromere

A

Limited systemic scleroderma/CREST

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23
Q

Widespread rash, pulmonary, anti-topoisomerase

A

Diffuse systemic scleroderma

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24
Q

p-ANCA, medium and small vessel vasculitis

A

Churg-Strauss

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25
Dry mouth, dry eyes, exocrine destruction, parotid swelling, arthralgia, raised ESR
Sjogren's
26
Saddle-shape nose, haemoptysis,haematuria, epistaxis, c-ANCA
Wegener's
27
Type IV collagen, haemoptysis, haematuria
Goodpasture's
28
Myelin basic protein, weakness in legs, blurred vision
Multiple sclerosis
29
Alkylating agent, used in SLE after steroids
Cyclophosphamide
30
CTLA4-immunoglobulin fusion protein, used in resistant RA
Abatacept
31
TNF-alpha antagonist,
Infliximab
32
Osteoporosis Tx, RANK ligand
Denosumab
33
Haematuria, after GI/resp infx, raised IgA
IgA nephropathy
34
Anti-sterptolysin O titre, sore throat 2 weeks prior
Post streptococcal glomerulonephritis
35
IgG/C3 immunofluorescence, end stage renal failure over a few days
Rapidly progressive glomerulonephritis
36
Most common causes of nephrotic syndrome in children, lack of structural change on light microscopy,
Minimal change disease
37
Deposition of IgA/IgM/IgG and C3 in GBM
Lupus nephritis
38
Test to diagnose sarcoidosis
Kveim test
39
Mutation of DeltaF508 on chromosome 7 effects which physical barrier
Mucociliary clearance
40
Clasical pathway def (C1q/r/s, C2 + C4) | Abnormal test and associated conditions
CH50 | SLE+RA
41
Alternative pathway def (Factors B/I/P) | Abnormal test and associated conditions
AH50 | Encapsulated bacteria
42
Cells involved in anaphylaxis+allergy
Mast cells release of IgE
43
Ab that protects resp, GI, lacrimal secretions
IgA
44
HLA DQ2
Coeliac's
45
HLA B27
Ankylosing spondylitis
46
HLA DR2, type II hypersens
Goodpastures
47
HLA DR3
Grave's, SLE, myasthenia gravis
48
HLA DR4
T1DM, RA
49
Alopecia, vitiligo, hypothyroidism, gonadal failure, T cell tolerance, AIRE
APECED
50
Autoimmune mechanism in rheumatic fever
Molecular mimicry
51
ABO incompatibility first immune response
C1
52
Demoglien , Nikolsky's sign
Pemphigus
53
Immediate reaction provoked by re-exposure to an allergen. | IgE mediated degranulation of mast cells = releasing inflammatory mediators
Type I hypersensitivity
54
Anaphylaxis, oral allergy syndrome, latex food syndrome, allergic rhinitis, acute urticaria, food allergy
Type I hypersensitivity
55
IgG or IgM Abs targeting self antigen fixed to cell surface.
Type II hypersensitivity
56
Haemolytic disease of the new born, AIHA, AITP, Goodpasture's, Pemphigus vulgaris, Graves, Myasthenia gravis,
Type II Hypersensitivity
57
Acute rheumatic fever, Pernicious anaemia, Churcg-Strauss, Wegener's, Microscopic polyangiitis Chronic urticaria
Type II hypersensitivity
58
IgG or IgM immune targeting self antigen not fixed to cell surface forming immune complexes
Type III Hypersensitivity
59
SLE, Polyarthritis nodusa, serum sickness (penicilllin reaction),
Type III hypersensitivity
60
Delayed hypersensitivity mediated by T cells
Type IV hypersensitivity
61
DM, MS, RA, Crohn's, contact dermatitis
Type IV hypersensitivity
62
Monoclonal Ab directed against IL-2 receptor | Kidney transplant
Basiliximab
63
Myaesthenic crisis
Plasmapheresis
64
CD20 monoclonal Ab
Rituximab
65
Fully human TNF-alpha monoclonal Ab
Adalimumab
66
Anti-glycoprotein IIb/IIIa on plts
Autoimmune thrombocytopenic purpura

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