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Flashcards in Block 1 Deck (19):
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What conditions are psammoma bodies found in?

Meningioma
Papillary carcinoma of thyroid and ovary

1

Opsonins.

IgG
C3b
C-reactive protein
MBL

2

LAD1.

AR
Deficiency of beta2 integrins
Recurrent bacterial infection and poor wound healing
Delayed separation of the umbilical cord

Rolling of leukocytes is unaffected

3

LAD 2.

Deficiency of selectin
Poor wound healing
Delayed separation of umbilical cord

Problems with rolling of leukocytes

4

Chediak-Higashi syndrome.

Defect in phagolysosome fusion
Prone to S. aureus and other infections
Neutrophils show giant, fused granules

Melanocytes abnormalities (partial oculocutaneous albinism and silvery hair)
Bleeding disorders
Death in childhood

5

Chronic granulomatous disease.

X-linked recessive
NADPH oxidase mutation
Absence of respiratory burst
Low superoxide production

6

PGE2.

Vasodilation, pain, fever

7

PGE2 alpha.

Contraction of uterine and bronchial muscle

8

PGI2 (prostacyclin).

Vasodilation
Inhibitor of platelet aggregation

9

TXA2 (thromboxane).

Vasoconstriction
Platelet aggregation
Bronchoconstriction

10

Leukotrienes.

Chemoattractant for leukocyte produced by leukocytes
LTB4 - activator of neutrophils
LTE4 - vasoconstriction, bronchospasm, increased vascular permeability
LTC4
LTD4

11

Lipoxins.

Inhibitors of inflammation
Inhibits neutrophils and leukocytes

12

Nitric oxide.

Recruits neutrophils
Inhibition of mast cell induced inflammation
Potent vasodilator
Reduces platelet aggregation and adhesion

13

PAF.

Vasoconstriction
Bronchoconstriction
Leukocyte adhesion
Chemotaxis

14

Vasodilation.

Prostaglandins
Histamine
NO

15

Increase vascular permeability.

Vasoactive amines
C3a and C5a
Bradykinin
Leukotrienes C4, D4, and E4
PAF
Substance P

16

Fever.

IL1
TNF
PGE2

17

Pain.

PGE2
Bradykinin

18

C-reactive protein.

Involved in necrosis with acute inflammation

Elevated in high risk MI, rheumatoid arthritis, and infections