Block 1 Flashcards
(19 cards)
Opsonins.
IgG
C3b
C-reactive protein
MBL
What conditions are psammoma bodies found in?
Meningioma
Papillary carcinoma of thyroid and ovary
LAD1.
AR
Deficiency of beta2 integrins
Recurrent bacterial infection and poor wound healing
Delayed separation of the umbilical cord
Rolling of leukocytes is unaffected
LAD 2.
Deficiency of selectin
Poor wound healing
Delayed separation of umbilical cord
Problems with rolling of leukocytes
Chediak-Higashi syndrome.
Defect in phagolysosome fusion
Prone to S. aureus and other infections
Neutrophils show giant, fused granules
Melanocytes abnormalities (partial oculocutaneous albinism and silvery hair)
Bleeding disorders
Death in childhood
Chronic granulomatous disease.
X-linked recessive
NADPH oxidase mutation
Absence of respiratory burst
Low superoxide production
PGE2.
Vasodilation, pain, fever
PGE2 alpha.
Contraction of uterine and bronchial muscle
PGI2 (prostacyclin).
Vasodilation
Inhibitor of platelet aggregation
TXA2 (thromboxane).
Vasoconstriction
Platelet aggregation
Bronchoconstriction
Leukotrienes.
Chemoattractant for leukocyte produced by leukocytes
LTB4 - activator of neutrophils
LTE4 - vasoconstriction, bronchospasm, increased vascular permeability
LTC4
LTD4
Lipoxins.
Inhibitors of inflammation
Inhibits neutrophils and leukocytes
Nitric oxide.
Recruits neutrophils
Inhibition of mast cell induced inflammation
Potent vasodilator
Reduces platelet aggregation and adhesion
PAF.
Vasoconstriction
Bronchoconstriction
Leukocyte adhesion
Chemotaxis
Vasodilation.
Prostaglandins
Histamine
NO
Increase vascular permeability.
Vasoactive amines C3a and C5a Bradykinin Leukotrienes C4, D4, and E4 PAF Substance P
Fever.
IL1
TNF
PGE2
Pain.
PGE2
Bradykinin
C-reactive protein.
Involved in necrosis with acute inflammation
Elevated in high risk MI, rheumatoid arthritis, and infections
