Block 10 - Week 1

Question 1

Enalapril , lisinopril and captopril

Answer 1

Competitive inhibitor of the angiotensin converting enzyme (ACE)

Question 2

Amiloride

Answer 2

Sodium channel blocker
Antikaliuretic diuretic agent

Antihypertensive , potassium sparing diuretic

Inhibits sodium reabsorption in the collecting ducts by Binding to sodium channels promoting loss of sodium and water whilst retaining potassium and hydrogen resulting in hyperkalaemic metabolic acidosis

Question 3

Furosemide

Answer 3

Sodium potassium chloride cotransporter inhibitor

Loop diuretic

Inhibits the transporter in the thick ascending limb of henle preventing sodium transport from the lumen of the loop into the basolateral interstitium causing retention of water - potent diuretic