Block 4

Question 1

Novel Injectables

For IM injections, how much can you inject?

Answer 1

2-5mL, larger than subQ inj

Question 2

Novel Injectables

For SubQ injection, how much can you inject?

Answer 2

1-2mL, smaller than IM inj

Question 3

Novel Injectables

IM vs SubQ, which one allows mild irritants to be used?

Answer 3

IM

Question 4

Novel Injectables

IM vs SubQ, which one only allows non-irritating substances?

Answer 4

SubQ

Question 5

Novel Injectables

Why does IM inj allow mild irritants?

Answer 5

Muscles are more vascular and have fewer sensory nerves

Question 6

Novel Injectables

What is the primary route of delivery for subQ inj?

Answer 6

Protein-based drugs

Question 7

Which novel inj solution allows controlled release to take place for months - year?

Answer 7

Polymer-based in situ forming systems

Question 8

Which novel inj solution has the shortest controlled release profile?

Answer 8

Oil-based solution

Question 9

What is the rate limiting step in oil-based novel injections?

Answer 9

Dissolution

Question 10

What is an iontophoresis?

Answer 10

Migration of ionic drug into tissue by electric current

Question 11

What are some advantages of iontophoresis?

Answer 11

1. Controlled delivery rate
2. Eliminates GI issues
3. Avoid risk of infection, inflammation, etc
4. Enhanced pt compliance

Question 12

What are some disadvantages of iontophoresis?

Answer 12

Irritation at high current densities

Question 13

What is a phonophoresis?

Answer 13

Transport of drug thru tissue via ultrasound

Question 14

With phonophoresis, what is the drug usually mixed with?

Answer 14

Coupling agent (gel, cream, etc)

Question 15

Which layer of the skin is involved with phonophoresis?

Answer 15

Stratum corneum

Question 16

Explain the caviation MOA of phonophoresis

Answer 16

Formation of small air bubbles leading to disordering of lipid bilayer forming a channel

Question 17

Explain the microstreaming MOA of phonophoresis

Answer 17

Efficient mixing by inducing eddies, which enhances dissolution

Question 18

Explain the heat generation MOA of phonophoresis

Answer 18

Converts ultrasound energy to heat energy

Question 19

“Pharmacy on a Chip” what is this?

Answer 19

Device designed to deliver 200 months (16yrs) worth of progestin for birth control

Question 20

“Accordion Pill” what is this?

Answer 20

Biodegradable polymeric film that is folded to an accordion shape stuffed into a capsule

Retains in stomach for 8 to 12 hours (up to 550mg)

Question 21

“Sushi Implant” what is this?

Answer 21

Treats T1DM, artificial pancreas

Question 22

What are the components of therapeutic nanoparticles?

Answer 22

1. Targeting mechanism
2. Destructive mechanism
3. Molecular packaging

Question 23

What is the size of a nanoparticle?

Answer 23

10^-9 m = 1nm

Question 24

In a liposome, what are hydrophilic and hydrophobic drug loaded at?

Answer 24

Hydrophilic - core

Hydrophobic - lipid bilayer

Question 25

MOA Doxil (Doxorubicin)?

Answer 25

Topoisomerase II inhibitor

Question 26

What is included in a batch analysis size technique?

Answer 26

DLS + SLS

Question 27

DLS + SLS is found in what sizing technique?

Answer 27

Batch analysis

Question 28

What is included in a separation-based analysis for sizing techniques?

Answer 28

FFF, LC, and AUC

Question 29

FFF, LC, and AUC is found in what sizing technique?

Answer 29

Separation-based analysis

Question 30

Dynamic Light Scattering vs Transmission Electron Microscopy Which one is faster?

Answer 30

DLS

Question 31

Dynamic Light Scattering vs Transmission Electron Microscopy Which one is slower?

Answer 31

TEM

Question 32

Dynamic Light Scattering vs Transmission Electron Microscopy Which one provides more accurate size?

Answer 32

TEM

Question 33

Dynamic Light Scattering vs Transmission Electron Microscopy Which one is hydrodynamic?

Answer 33

DLS

Question 34

Pros/Cons of Stable nanomedicines?

Answer 34

Stable, easy to manufacture Useless

Question 35

Pros/Cons of Metastable nanomedicines?

Answer 35

Useful Expensive to make + store

Question 36

What is Q1 equivalency?

Answer 36

Same material

Question 37

What is Q2 equivalency?

Answer 37

Same concentration

Question 38

What is Q3 equivalency?

Answer 38

Particle size (or other physiochemical properties)