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Flashcards in Block A Deck (327)
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1

4 subunits that can make intermediate filaments

keratin, laminin, neurofilaments, and vimentin

2

up to ____% of protein in cell is actin

20

3

Actin filaments require 3 things for polymerization

K+, Mg2+ and ATP

4

cut actin filaments are called

gelsolin

5

an actin capping protein

tropomodulin

6

an actin cross-linking protein

spectrin

7

are intermediate filaments polar?

no

8

Keratins have highly conserved ____ domain and highly variable _____ domain

globular (terminal)
central

9

most abundant IF

vimentin

10

IF protein mostly found in muscle

desmin

11

keratins will span the cytoplasm of _____ cells

epithelial

12

Microtubules are a circle composed of ____ alpha/beta tubulin dimers

13

13

formation of microtubule at MTOC is characterized by the presence of ____ tubulin

gamma

14

____ tubulin is at the minus end of a microtubule
___ tubulin is at the positive end

alpha
beta

15

do minus end of microtubules grow?

no

16

microtubule remodeling is linked to a pattern of ___ hydrolysis

GTP

17

all microtubules can be disassemble by

putting them in the cold

18

proteins responsible for transport along microtubule track

molecular motor proteins

19

molecular motor protein that moves toward minus end of microtube

dynein

20

molecular motor protein that moves toward plus end of microtube

kinesin

21

centrioles are built from what subunits

9 microtubule triplets

22

keratin IFs can connect with the keratins of other cells via

desmosomes

23

IFs form ________ filaments (only 1 type of protein)

homopolymeric

24

easiest way to distinguish between centriole and cilia

cilia has doublet in middle

25

each cilium requires a ____ as its organizing center

basal body

26

basal body is formed by:

repeated replications of the centrioles and their migration to the apical surface

27

during mitosis, _____ microtubules are formed around each centriole. they are crucial for alignment of the mitotic spindle

astral

28

Centrosome cycle-
Describe disengagement, duplication, engagement, maturation, and separation.

Disengagement- 2 centrioles break up, but are still tethered
duplication- each centriole makes a new centriole
engagement- new centrioles mature and the mother/daughter centrioles detach from each other
maturation- 2 individual centrosomes now mature and collect raw materials
separation- 2 centrosomes make spindle fibers between themselves

29

astral microtubules assure that:

centrioles are oriented properly

30

polar microtubules do what?`

help push dividing cells apart