block L1 Flashcards
name 5 innate immune cells?
neutrophils, monocytes, NK cells, mast cells, eosinophil, basophil
adaptive immune cells?
T lymphocytes, B
lymphoctyes
what happens when red blood cells are passed through impedance test?
Haemoglobin contains iron which
changes the flow of current proportional
to iron concentration.
formation of blood cells name and where?
haemopoeisis in bone marrow
what two types of progenitor cells do haemopoietic cells differentiate into?
common myeloid and common lymphoid
what type of cells do common myeloid cells produce?
innate immune cells
during foetal development where are the sites of haemopoeisis?
yolk sac, spleen and liver predominantly
what is the progenitor cell of platelets?
megakaryocytes
what is erythropoeisis regulated by?
erythropoeitin
what is platelet formation regulated by?
thrombopoetin
what regulates haemopoeisis?
growth factor
what is spectrin?
a cytoskeletal protein that forms a scaffold maintaining the integrity and shape of
the RBC membrane.
what is ankyrin?
Anchoring of ion channels to spectrin skeleton of RBC
what does band 4.1 protein do?
Key role in regulating membrane stability by stabilizing spectin-actin
cytoskeleton interactions, forming the erythrocyte membrane skeleton, mutations in Band 4.1
protein lead to anaemia
what does band 3 protein do?
Exchange of chloride and bicarbonate ions across
membrane, it has a key role in CO2 uptake by RBCs.
