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Flashcards in block L1 Deck (26)
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1
Q

name 5 innate immune cells?

A

neutrophils, monocytes, NK cells, mast cells, eosinophil, basophil

2
Q

adaptive immune cells?

A

T lymphocytes, B

lymphoctyes

3
Q

what happens when red blood cells are passed through impedance test?

A

Haemoglobin contains iron which
changes the flow of current proportional
to iron concentration.

4
Q

formation of blood cells name and where?

A

haemopoeisis in bone marrow

5
Q

what two types of progenitor cells do haemopoietic cells differentiate into?

A

common myeloid and common lymphoid

6
Q

what type of cells do common myeloid cells produce?

A

innate immune cells

7
Q

during foetal development where are the sites of haemopoeisis?

A

yolk sac, spleen and liver predominantly

8
Q

what is the progenitor cell of platelets?

A

megakaryocytes

9
Q

what is erythropoeisis regulated by?

A

erythropoeitin

10
Q

what is platelet formation regulated by?

A

thrombopoetin

11
Q

what regulates haemopoeisis?

A

growth factor

12
Q

what is spectrin?

A

a cytoskeletal protein that forms a scaffold maintaining the integrity and shape of
the RBC membrane.

13
Q

what is ankyrin?

A

Anchoring of ion channels to spectrin skeleton of RBC

14
Q

what does band 4.1 protein do?

A

Key role in regulating membrane stability by stabilizing spectin-actin
cytoskeleton interactions, forming the erythrocyte membrane skeleton, mutations in Band 4.1
protein lead to anaemia

15
Q

what does band 3 protein do?

A

Exchange of chloride and bicarbonate ions across

membrane, it has a key role in CO2 uptake by RBCs.

16
Q

what is the key role of macrophages in the spleen

A

removal of damaged red blood cells

17
Q

shape of RBCs?

A

biconcave disc

18
Q

site of thrombopoeitin production?

A

thrombopoeitin is produced by the liver

and kidney

19
Q

relest of platelets in he blood stream location and how?

A

Platelet reserves are found in the spleen that

can be released by splenic contraction

20
Q

process of platelet formation?

A

form from the cytoplasm and bud off from the membrane

21
Q

granules platelets contain and their contents?

A

Dense Granules: Contain ADP/ATP, calcium and serotonin helps to stimulate aggregation
Lambda Granules: Contain hydrolytic enzymes
Alpha Granules: Platelet factor 4

22
Q

Polycythemia vera?

A

Polycythemia vera

An excess of red blood cells in the circulation

23
Q

Essential thrombocythemia

A

Essential thrombocythemia

An excess of platelets

24
Q

Idiopathic myelofibrosis

A

Too few RBC, too many platelets and WBC

25
Q

Primary polycythemia ?

A

Genetic problems in RBC

26
Q

Secondary polycythemia

A

Due to conditions that promote RBC development