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Flashcards in Block one high yield Deck (67)
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1

pluripotent stem cell + IL-3

lymphoid progenitor

2

pluripotent stem cell + IL-3 + GM-CSF

myeloid progenitor

3

plasma vs serum?

plasma has fibrinogen

serum does not

4

3 RBC cytoskeleton proteins:

spectrin

ankyrin

actin

5

no ankyrin inRBC --> ?

hereditary spherocytosis

6

myeloperoxidase

neutrophil

Azurophilic granule

7

lysozyme

lactoferrin

neutrophilic specific granules

8

gelatinase

tertiary granules

9

major basic protein

cationic protein

Eosinophil specific granules

10

Bid/Bax

pro-apoptotic

11

Bcl-2/Bid

antiapoptotic

12

genome: dsRNA segmented

tropism: pro-erythroblasts

travel to mountain west

Colorado tick fever virus

13

genome: dsDNA

tropism: systemic; latent in CD34+ cells (monocyte-->macrophage)

heterophile Ab negative

Owl’s eyes cells

Congenital --> deafness

Cytomegalovirus

14

genome: dsDNA

tropism: CD4+ T cells, others: PBMNCs, epithelial cells

exanthem subitum (aka roseola): rash that develops after a fever resolves

heterophile Ab negative mononuceosis

HHV6, HHV7

15

genome: dsDNA

tropism:
Acute: epithelial cells of oropharynx (supports lytic life cycle)
Latent: B cells

infectious mononucleosis: Heterophile Ab positive mono

Burkitt lymphoma: t(8:14)
Hodgkin & non-Hodgkin lymphoma
nasopharyngeal lymphoma
X-linked lymphoproliferative disease: inherited mutation in SAP adapter

Epstein Bar virus

16

genome: dsDNA

tropism: epithelial cells; B cells

in immunocompromised patients only:

primary effusion lymphoma

multifocal Castlemans disease

Karposis sarcoma virus

17

genome: ssRNA + or -

tropism: erythroid progenitor cells

NO envelope

erythema infectiosum: fiery red rash on cheek.

Transient aplastic crisis: in patients with underlying anemia

parvovirus B19

18

genome: ssRNA+

tropism: T-cells

Acute T cell lymphoma / leukemia (ATL): Viral transcription factor Tax drives proliferation; blocks apoptosis.

HAM/TSP: Inflammation on the spine

Human T-cell Lymphoma virus 1 and 2

1 > CD4's

2> CD8's

19

genome: ssRNA -

tropism: macrophages

capsid: HELICAL

Hemorrhagic fever

Ebola

20

T-cell zone of lymph node

paracortex (deep)

21

Lymph flow through node...

Afferent lymphatic vessels

Subcapsular sinus

Trabecular sinus

Paracortical sinus

Medullary sinus

Efferent lymphatic vessel

22

Prevents antigen in blood from entering thymic cortex

Blood-thymus barrier

23

Largest lymphatic organ

spleen

24

TLR ?

dsRNA

TLR 3

25

TLR ?

LPS

TLR 4

26

TLR ?

Triacyl Lipoprotein

TLR 1 and 2

27

TLR ?

Diacyl Lipoprotein

TLR 6 and 2

28

TLR ?

flagellin

TLR 5

29

TLR ?

ssRNA

TLR 7/8

30

TLR ?

CpG-DNA

TLR 9