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IHO week 6 and Final > Block 5 highish yield > Flashcards

Block 5 highish yield Flashcards

1
Q

reduced IL-2 and expression of IL-2R (CD25) is a result of:

A

reduced antigen exposure

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2
Q

no Tregs

A

IPEX

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3
Q

problem caused by IPEX

A

out of control T-cells

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4
Q

Treg autocrine cytokine?

A

IL-35

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5
Q

genetic cause of IPEX

A

mutated FOXP3

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6
Q

overexpression of thyroid hormones

A

Grave’s disease

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7
Q

high MHC II induces

A

Th1

Th17

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8
Q

low MHC II induces

A

Th2

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9
Q

CXCR3

CCR5

A

Th1

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10
Q

CCR3

CCR4

CCR8

A

Th2

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11
Q

CCR6

A

Th17

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12
Q

Mutation in CCR5

A

HIV resistance

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13
Q

anti-nuclear antibodies

A

SLE

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14
Q

dsDNA and Smith (Sm) antigen antibodies

A

SLE

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15
Q

SLE hypersensitivity

A

Type III

immune complex mediated

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16
Q

anti-phospholipid antibodies

17
Q

acute necrotizing vasculitits

18
Q

SS-A

HLA-DR3

A

Subacute cutaneous LE

19
Q

autoantibodies for CCPs

20
Q

dry eyes

dry mouth

SS-A

SS-B

A

Sjogren Syndrome

21
Q

perivascular fibrosis

A

systemic sclerosis

22
Q

Scl-70 antibodies

A

systemic sclerosis

23
Q

anti-centromere antibodies

A

CREST syndrome

24
Q

Raynaud’s

A

systemic sclerosis

25
anti-U1-RNP
mixed connective tissue disease
26
Btk
XLA
27
B-cells present don't differentiate into plasma cells
CVID
28
failure of thymus development
DiGeorge
29
22q11
DiGeorge
30
X-linked recessive CD40L mutation
Hyper IgM syndrome
31
P. jiroveci
Hyper IgM syndrome
32
defect in humoral and cell mediated immunity usually X-linked gamma chain cytokine receptor mutation
SCID
33
ADA
SCID
34
Thrombocytopenia Eczema variable loss of cell mediated immunity
Wiskott-Aldrich
35
inability to clear EBV infectious mono B cell lyphoma
X-linked lymphoproliferative disorder

IHO week 6 and Final (14 decks)

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