Blood Flashcards
(53 cards)
plasma
liquid part of blood (90% is water)
Erythocytes
red blood cells (RBCs)
Leukocytes
white blood cells (WBCs)
Thrombocytes
platlets
Plasma
-90% water
-liquid medium for carrying materials in blood
-absorb heat produced by the cellular tissue
-expels heat when blood is near the skin
substances dissolved in plasma
-inorganic solutes: Na+, Cl-, K+
-organic constituents: plasma proteins, nutrients, dissolved gasses, waste products, hormones
function of plasma proteins
establish osmotic gradient
help buffer changes in pH
3 types of plasma proteins
-albumins
-globulins
-fibrinogen
Albumin
-most abundant in plasma
-contribute to the colloid osmotic pressure gradient between blood and interstitial fluid
Globulins
-alpha, beta: bind poorly water soluble substances, involved in blood-clotting process
-alpha: can activate some plasma proteins
-gamma: immunoglobulins (antibodies) essential for body
Fibrinogen
key factor in blood clotting
erythrocytes
-lack of nucleus and organelles
-main function is o2 transport in the blood
Eryothrocyte enzymes
-glycolitic enzymes: energy for cell
-carbonic anhydrase: co2 transport
Erythropoiesis (RBC production) in the red bone marrow
in mature humansred bone marrow areas are in sternum, ribsm pelvis, and the upper end of the limb bones. Stem cells and immaure (RBCs are mixed in cone marrow. when they mature they are released into the capillaries in the bone marrow and circulate throughout the body
role of hemoglobin
found in red blood cells
-made of globin and 4 heme groups
-each heme group can bind to one o2 molecule
heme binds to co2 to
transport it from tissues back to the lungs
heme binds to H+ to
(hemoglobin) minimizes change to pH
heme binds to CO to
blocks O2 binding, suffocation (CO posioning)
heme binds to NO to
relax/dialate local artirioles
anemia
below normal o2 carrying capacity of the blood due to a lower hematocrit
nutritiona anemia
dietary (iron) deficency , not enough iron to synthesize hemoglobin
aplastic anemia
bone marrow fails to produce enough RBCs (possibly due to invasion of bone marrow by cancer cells or following chemotherapy)
renal anemia
kidney disease can lead to inadequare EPO secretion
hemorrhagic anemia
loss of blood due to acute bleeding or chronic period