Blood and immune 1 Flashcards
(23 cards)
problem with circulation time
very fast so disease spreads quickly
Blood functions
Transportation
Regulation - temperature, pH, salinity
Protection - Leakage control system: blood clotting
Immune system: surveillance circuit, white blood cells and antibody molecules
Blood Components(2)
55% Plasma
45% Formed elements
antigen
anything that stimulates the immune system
Centrifuge order
plasma on top
formed elements bottom
platelets function
clotting
Plasma components
7% Proteins
- 5% Water
- 5% Solutes
Plasma proteins
54% Albumin: osmotic balance and pH buffering
38% Globulins - Immunoglobulin (antibody molecule): defence
7% Fibrinogen: clotting
Formed elements components
Platelets 2
WBC 3
RBC 99%
White blood cell components
70% neutrophils (60-70%) 22% lymphocytes (20-25%) Monocytes (3-8%) Eosinophils (2-4%) Basophils (0.5-1%)
lymph flow
Some components of the blood pass through the capillary wall into tissue and become interstitial fluid, which re-circulates, returning to the blood via the ducts of the lymphatic system
other solutes
such as electrolytes nutrients gases regulatory substances vitamins waste products
Plasma functions
It is the solvent for carrying other substances
osmotic balance
regulation of membrane permeability
Clotting
It is automatic, a “blood clotting system” to seal circulation leaks, and involves cellular fragments (platelets) and a number of interacting proteins (specifically fibrinogen)
Physical characteristics of blood?
- Vicious
- Without added anticoagulant, it will clot (I.e separates into a red gel and a straw coloured liquid called serum).
- the clot consists of blood cells trapped in a network of protein fibres formed by protein fibrin
What is serum?
It is the plasma (non-cellular blood portion) minus the clotting proteins
Volume of blood in adult and newborn
5L
300ml
how much blood circulates through heart daily
14000L per day through heart
Circulation time and amount in each pump
1 minute
70ml
How much blood transports through capillary walls daily
3L daily
Becomes interstitial fluid
recirculates via ducts of lymphatic system
RBC count
4.8 to 5.4 mill per ul
Platelet count
150000 to 400000 per ul
WBC count
5000-10000 per uL