Blood immune 2

Question 1

RBC features

Answer 1

Biconcave
Huge turnover - 120 day normal lifetime
Originate from myeloid stem cells in bone marrow - reticulocytes

Question 2

Haemoglobin and Heme

Answer 2

4 Chains - 2a - 142 amino acids
2b - 146 amino acids

each binds to one 02 via iron contraining heme group

Embryonic fetal and adult

Question 3

sickle

Answer 3

Glutame to valine

Question 4

Serum Albumin

Answer 4

singl eamino acid chain 585 amino acids

Main part of plasma

Serves as carrier for insoluble smaller molecules - eg. steroids, lipids, hormones, man-made drugs like aspirin etc.

Consequently - important for drug design. If drugs are to carried around the body, they should bind correctly to albumin.

entirely alpha helical

5 lipid molecules

35mg/ml

Question 5

Antibody - Immunoglobulin

Answer 5

two identical heavy chains 434 amino acids
2 identical light chains 213 amino acids

12 Ig domains

Question 6

Antibody diagram

Answer 6

Epitope does the acutal recognition(side chains)

Modular structure of single repeated immunoglobular domains. there are 12 of these 12

all beta

20mg/ml in serum

Question 7

Domain

Answer 7

area that folds into same 3D shape

Question 8

B cell antibody

Answer 8

Each B cell makes immunoglobulin molecules of the same antigen-binding specificity, and in addition a membrane-bound version of immunoglobulin also with the same specificity, which remains attached to the B cell.

Question 9

RBC lifespan

Answer 9

120 days

Question 10

blood types

Answer 10

different carbohydrate group attached